Neurocognitive profile analysis in obsessive-compulsive disorder

被引:35
作者
Burdick, Katherine E. [1 ,2 ,3 ]
Robinson, Delbert G. [1 ,2 ,3 ]
Malhotra, Anil K. [1 ,2 ,3 ]
Szeszko, Philip R. [1 ,2 ,3 ]
机构
[1] Zucker Hillside Hosp, N Shore Long Isl Jewish Hlth Syst, Div Psychiat Res, Glen Oaks, NY 11004 USA
[2] Albert Einstein Coll Med, Dept Psychiat, New York, NY USA
[3] Feinstein Inst Med Res, Ctr Translat Psychiat, Manhasset, NY USA
关键词
OCD; neurocognition; motor; processing speed; basal ganglia; anxiety;
D O I
10.1017/S1355617708080727
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Although neurocognitive deficits have been identified in obsessive-compulsive disorder (OCD), little research has focused whether these deficits are generalized or specific to a given cognitive domain. We assessed the relative strengths and weaknesses of 26 adult patients with OCD compared to 38 age- and sex-matched healthy volunteers in domains of motor. verbal memory, visual memory, reasoning/problem solving,. processing speed processing, and language. Profile analysis revealed an overall neurocognitive deficit of standard deviation in OCD patients versus healthy Volunteers. With relative weaknesses in motor and processing speed domains. In contrast, relative strengths were observed in language. verbal memory. and reasoning/problem solving. Our findings demonstrate neurocognitive impairment in OCD that may relate to functional outcome in this population. Findings of specific abnormalities on tasks of motor and processing speed are consistent with a hypothesized role of thalamocortical and basal ganglia regions in the pathogenesis of OCD.
引用
收藏
页码:640 / 645
页数:6
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