Constituents from Vigna vexillata and Their Anti-Inflammatory Activity

被引：20

作者：

Leu, Yann-Lii ^{[2
,3
]}

Hwang, Tsong-Long ^{[2
,3
]}

Kuo, Ping-Chung ^{[1
]}

Liou, Kun-Pei ^{[1
]}

Huang, Bow-Shin ^{[1
]}

Chen, Guo-Feng ^{[4
]}

机构：

[1] Natl Formosa Univ, Dept Biotechnol, Yunlin 632, Taiwan

[2] Chang Gung Univ, Grad Inst Nat Prod, Tao Yuan 333, Taiwan

[3] Chang Gung Univ, Chinese Herbal Med Res Team, Hlth Aging Res Ctr, Tao Yuan 333, Taiwan

[4] Natl Chung Hsing Univ, Dept Chem, Taichung 402, Taiwan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2012年 / 13卷 / 08期

关键词：

Vigna; isoflavone; anti-inflammatory; superoxide anion; elastase; HOT-WATER EXTRACT; CHEMICAL-CONSTITUENTS; AZUKI-BEANS; ANGULARIS; NEUTROPHILS; LEAVES; CELLS; RATS; GENISTEIN; STEROIDS;

D O I：

10.3390/ijms13089754

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The seeds of Vigna genus are important food resources and there have already been many reports regarding their bioactivities. In our preliminary bioassay, the chloroform layer of methanol extracts of V. vexillata demonstrated significant anti-inflammatory bioactivity. Therefore, the present research is aimed to purify and identify the anti-inflammatory principles of V. vexillata. One new sterol (1) and two new isoflavones (2,3) were reported from the natural sources for the first time and their chemical structures were determined by the spectroscopic and mass spectrometric analyses. In addition, 37 known compounds were identified by comparison of their physical and spectroscopic data with those reported in the literature. Among the isolates, daidzein (23), abscisic acid (25), and quercetin (40) displayed the most significant inhibition of superoxide anion generation and elastase release.

引用

页码：9754 / 9768

页数：15

共 60 条

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