Drug release of pH/temperature-responsive calcium alginate/poly(N-isopropylacrylamide) semi-IPN beads

被引：140
作者：
Shi, Jun
Alves, Natalia M.
Mano, Joao F.
机构：
[1] Univ Minho, 3Bs Res Grp Biomat Biodegradables & Biomimet, P-4710057 Braga, Portugal
[2] Univ Minho, Polymer Engn Dept, P-4800058 Guimaraes, Portugal
来源：
MACROMOLECULAR BIOSCIENCE | 2006年 / 6卷 / 05期
关键词：
alginate; biomaterials; drug delivery systems; pH/temperature responsive;
D O I：
10.1002/mabi.200600013
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of semi-interpenetrating, polymer network (semi-IPN), hydrogel beads, composed of calcium alginate (Ca-alginate) and poly(N-isoproplyacrylamide) (PNIPAAM), were prepared for a pH/temperature-sensitive drug delivery study. The equilibrium swelling showed the independent pH- and thermo- responsive nature of the developed materials. At pH=2.1, the release amount of indomethacin incorporated into these beads was about 10% within 400 min, while this value approached to 95% at pH=7.4. The release rate of the drug was higher at 37 degrees C than at 25 degrees C and increased slightly with increasing PNIPAAM content. These results suggest that the Ca-alginate/PNIPAAM beads have the potential to be used as an effective pH/temperature sustainable delivery system of bioactive agents.
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收藏
页码：358 / 363
页数：6
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