The emergence of phox-ER stress induced immunogenic apoptosis

被引：94

作者：

Garg, Abhishek D. ^{[1
]}

Krysko, Dmitri V. ^{[2
,3
]}

Vandenabeele, Peter ^{[2
,3
]}

Agostinis, Patrizia ^{[1
]}

机构：

[1] Univ Leuven KULeuven, Dept Cellular & Mol Med, Cell Death Res & Therapy Unit, Louvain, Belgium

[2] VIB, Mol Signaling & Cell Death Unit, Dept Mol Biomed Res, Ghent, Belgium

[3] Univ Ghent, Dept Biomed Mol Biol, B-9000 Ghent, Belgium

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 05期

关键词：

photodynamic therapy; calreticulin; ATP; phox-ER stress; immunogenic apoptosis; EXPOSURE; CANCER;

D O I：

10.4161/onci.19750

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Primary induction of photo-oxidative (phox)-ER stress in cancer cells evoked immunogenic apoptosis (IA) associated with pre-apoptotic emission of calreticulin and ATP, and protective antitumor immunity. This IA subroutine involved "core" functions (e.g., PERK/ PI3K-based modulation of secretory trafficking) rather than "private" ones (caspase-8 and eIF2 alpha-phosphorylation) engaged by other IA inducers.

引用

页码：786 / 788

页数：3

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