Biology and immunology of cancer stem(-like) cells in head and neck cancer

被引：40

作者：

Qian, Xu ^{[1
,2
]}

Ma, Chenming ^{[2
]}

Nie, Xiaobo ^{[1
]}

Lu, Jianxin ^{[1
]}

Lenarz, Minoo ^{[2
]}

Kaufmann, Andreas M. ^{[3
]}

Albers, Andreas E. ^{[2
]}

机构：

[1] Wenzhou Med Univ, Zhejiang Prov Key Lab Med Genet, Key Lab Lab Med, Minist Educ, Wenzhou, Zhejiang, Peoples R China

[2] Charite, Dept Otorhinolaryngol Head & Neck Surg, D-12200 Berlin, Germany

[3] Charite, Clin Gynecol, D-12200 Berlin, Germany

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2015年 / 95卷 / 03期

关键词：

Cancer stem cells; ALDH1; Epithelial-mesenchymal transition; Human papillomavirus; Immunotherapy; Vaccination; STEM-LIKE CELLS; TO-MESENCHYMAL TRANSITION; ANTIGEN-PROCESSING MACHINERY; ALDEHYDE DEHYDROGENASE 1; TUMOR-INITIATING CELLS; PROSTATE-CANCER; SELF-RENEWAL; BREAST-CARCINOMA; IMMUNE-RESPONSE; IN-VITRO;

D O I：

10.1016/j.critrevonc.2015.03.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immunological approaches against tumors including head and neck squamous cell carcinoma (HNSCC) have been investigated for about 50 years. Such immunotherapeutic treatments are still not sufficiently effective for therapy of HNSCC. Despite the existence of immuno-surveillance tumor cells may escape from the host immune system by a variety of mechanisms. Recent findings have indicated that cancer stem(-like) cells (CSCs) in IINSCC have the ability to reconstitute the heterogeneity of the bulk tumor and contribute to immunosuppression and resistance to current therapies. With regard to the CSC model, future immunotherapy possibly in combination with other modes of treatment should target this subpopulation specifically to reduce local recurrence and metastasis. In this review, we will summarize recent research findings on immunological features of CSCs and the potential of immune targeting of CSCs. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：337 / 345

页数：9

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