VEGFR-1/FLT-1 is induced by protein kinase C and its Ectodomain Cleavage is regulated by glycosylation and metalloproteases

被引:0
|
作者
Raikwar, Nandita S. [1 ]
Liu, Kang Z. [1 ]
Thomas, Christie P. [1 ,2 ]
机构
[1] Univ Iowa, Coll Med, Dept Internal Med, Iowa City, IA 52242 USA
[2] VA Med Ctr, Iowa City, IA USA
关键词
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页数:1
相关论文
共 50 条
  • [31] Expression of VEGFR-1 (Flt-1) in breast cancer is associated with VEGF expression and with node-negative tumour stage
    Schmidt, Melanie
    Voelker, Hans-Ullrich
    Kapp, Michaela
    Dietl, Johannes
    Kammerer, Ulrike
    ANTICANCER RESEARCH, 2008, 28 (3A) : 1719 - 1724
  • [32] VEGFR-1/Flt-1 inhibition increases angiogenesis and improves muscle function in a mouse model of Duchenne muscular dystrophy
    Bosco, Jennifer
    Zhou, Zhiwei
    Gabriels, Sofie
    Verma, Mayank
    Liu, Nan
    Miller, Brian K.
    Gu, Sheng
    Lundberg, Dianna M.
    Huang, Yan
    Brown, Eilish
    Josiah, Serene
    Meiyappan, Muthuraman
    Traylor, Matthew J.
    Chen, Nancy
    Asakura, Atsushi
    De Jonge, Natalie
    Blanchetot, Christophe
    de Haard, Hans
    Duffy, Heather S.
    Keefe, Dennis
    MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2021, 21 : 369 - 381
  • [33] Expression of receptor tyrosine kinases VEGFR-1 (FLT-1), VEGFR-2 (KDR), EGFR-1, PDGFRα and c-Met in canine primary brain tumours
    Dickinson, P. J.
    Roberts, B. N.
    Higgins, R. J.
    Leutenegger, C. M.
    Bollen, A. W.
    Kass, P. H.
    LeCouteur, R. A.
    VETERINARY AND COMPARATIVE ONCOLOGY, 2006, 4 (03) : 132 - 140
  • [34] Involvement of VEGFR-2 (kdr/flk-1) but not VEGFR-1 (flt-1) in VEGF-A and VEGF-C-induced tube formation by human microvascular endothelial cells in fibrin matrices in vitro
    Koolwijk P.
    Peters E.
    Van Der Vecht B.
    Hornig C.
    Weich H.A.
    Alitalo K.
    Hicklin D.J.
    Wu Y.
    Witte L.
    Van Hinsbergh V.W.M.
    Angiogenesis, 2001, 4 (1) : 53 - 60
  • [35] Neutralizing MoAb to VEGF receptors inhibit proliferation and migration of a subset of human leukemias through interaction with VEGFR-2(KDR) and VEGFR-1(FLT-1).
    Dias, S
    Lane, WJ
    Wu, Y
    Choy, M
    Peichev, M
    Chadburn, A
    Hyjeck, E
    Roboz, G
    Hicklin, D
    Witte, L
    Rafii, S
    BLOOD, 1999, 94 (10) : 620A - 620A
  • [36] The vascular endothelial growth factor (VEGF) receptor Flt-1 (VEGFR-1) modulates Flk-1 (VEGFR-2) signaling during blood vessel formation
    Roberts, DM
    Kearney, JB
    Johnson, JH
    Rosenberg, MP
    Kumar, R
    Bautch, VL
    AMERICAN JOURNAL OF PATHOLOGY, 2004, 164 (05) : 1531 - 1535
  • [37] VEGFR-1 (FLT-1) activation modulates acute lymphoblastic leukemia localization and survival within the bone marrow, determining the onset of extramedullary disease
    Fragoso, R
    Pereira, T
    Wu, Y
    Zhu, ZP
    Cabeçadas, J
    Dias, S
    BLOOD, 2006, 107 (04) : 1608 - 1616
  • [38] N-Terminal Cleavage and Release of the Ectodomain of Flt1 Is Mediated via ADAM10 and ADAM 17 and Regulated by VEGFR2 and the Flt1 Intracellular Domain
    Raikwar, Nandita S.
    Liu, Kang Z.
    Thomas, Christie P.
    PLOS ONE, 2014, 9 (11):
  • [39] A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits vascular endothelial growth factor-dependent phosphatidylinositol 3′-kinase activation and endothelial cell migration
    Gille, H
    Kowalski, J
    Yu, LL
    Chen, H
    Pisabarro, MT
    Davis-Smyth, T
    Ferrara, N
    EMBO JOURNAL, 2000, 19 (15) : 4064 - 4073
  • [40] Human cancer cell lines resistant to EGFR inhibitors acquire an altered expression of VEGFR-1/Flt-1 and become sensitive to ZD6474
    Bianco, Roberto
    Daniele, Gennaro
    Gelardi, Terese
    Tuccillo, Concetta
    Ryan, Anderson J.
    Bianco, A. Raffaele
    De Placido, Sabino
    Ciardiello, Fortunato
    Tortora, Giampaolo
    CANCER RESEARCH, 2006, 66 (08)