Effects of Early Intraoral Acesulfame-K Stimulation to Mice on the Adults Sweet Preference and the Expression of -Gustducin in Fungiform Papilla

被引:15
作者
Chen, Meng-Ling [1 ]
Liu, Si-Si [2 ]
Zhang, Gen-Hua [1 ]
Quan, Ying [1 ]
Zhan, Yue-Hua [1 ]
Gu, Tian-Yuan [1 ]
Qin, Yu-Mei [3 ]
Deng, Shao-Ping [3 ]
机构
[1] Changshu Inst Technol, Sch Biosci & Food Engn, Sensory Sci Lab, Changshu 215500, Jiangsu, Peoples R China
[2] Soochow Univ, Cell Biol Lab, Suzhou 215000, Peoples R China
[3] Zhejiang Gongshang Univ, Coll Food Sci & Biotechnol, Hangzhou 310035, Zhejiang, Peoples R China
基金
中国国家自然科学基金;
关键词
acesulfame-K; -Gustducin; mouse; sweet preference; taste bud; TASTE BUD DISTRIBUTION; ALPHA-GUSTDUCIN; SOFT PALATE; RECEPTOR; RAT; FLAVOR; RESPONSES; PATTERNS; CONSUMPTION; ACCEPTANCE;
D O I
10.1093/chemse/bjt001
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Exposure to artificial sweetener acesulfame-K (AK) at early development stages may influence the adult sweet preference and the periphery gustatory system. We observed that the intraoral AK stimulation to mice from postnatal day 4 (P4) to weaning decreased the preference thresholds for AK and sucrose solutions in adulthood, with the preference pattern unchanged. The preference scores were increased in the exposure group significantly when compared with the control group at a range of concentrations for AK or sucrose solution. Meanwhile, more -Gustducin-labeled fungiform taste buds and cells in a single taste bud were induced from week 7 by the early intraoral AK stimulation. However, the growth in the number of -Gustducin-positive taste bud or positive cell number per taste bud occurred only in the anterior region, the rostral 1-mm part, but not in the intermediate region, the caudal 4-mm part, of the anterior two-third of the tongue containing fungiform papillae. This work extends our previous observations and provides new information about the developmental and regional expression pattern of -Gustducin in mouse fungiform taste bud under early AK-stimulated conditions.
引用
收藏
页码:447 / 455
页数:9
相关论文
共 52 条
[1]   FTIR determination of aspartame and acesulfame-k in tabletop sweeteners [J].
Armenta, S ;
Garrigues, S ;
de la Guardia, M .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2004, 52 (26) :7798-7803
[2]   Ethanol consumption and taste preferences in C57BL/6ByJ and 129/J mice [J].
Bachmanov, AA ;
Tordoff, MG ;
Beauchamp, GK .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1996, 20 (02) :201-206
[3]   Sweetener preference of C57BL/6ByJ and 129P3/J mice [J].
Bachmanov, AA ;
Tordoff, MG ;
Beauchamp, GK .
CHEMICAL SENSES, 2001, 26 (07) :905-913
[4]   Voluntary sodium chloride consumption by mice: Differences among five inbred strains [J].
Bachmanov, AA ;
Tordoff, MG ;
Beauchamp, GK .
BEHAVIOR GENETICS, 1998, 28 (02) :117-124
[5]   Early Flavor Learning and Its Impact on Later Feeding Behavior [J].
Beauchamp, Gary K. ;
Mennella, Julie A. .
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2009, 48 :S25-S30
[6]  
Boughter JD, 1997, J NEUROSCI, V17, P2852
[7]   Comparison of the responses of the chorda tympani and glossopharyngeal nerves to taste stimuli in C57BL/6J mice [J].
Danilova, V ;
Hellekant, G .
BMC NEUROSCIENCE, 2003, 4 (1)
[8]   Taste responses to sweet stimuli in α-gustducin knockout and wild-type mice [J].
Danilova, Vicktoria ;
Damak, Sami ;
Margolskee, Robert F. ;
Hellekant, Goeran .
CHEMICAL SENSES, 2006, 31 (06) :573-580
[9]   Food reward in the absence of taste receptor signaling [J].
de Araujo, Ivan E. ;
Oliveira-Maia, Albino J. ;
Sotnikova, Tatyana D. ;
Gainetdinov, Raul R. ;
Caron, Marc G. ;
Nicolelis, Miguel A. L. ;
Simon, Sidney A. .
NEURON, 2008, 57 (06) :930-941
[10]  
Drewnowski A, 2001, DRUG METAB DISPOS, V29, P535