DNA repair - Tails of histones lost

被引：15

作者：

Nussenzweig, A

Paull, T

机构：

[1] NIH, Expt Immunol Branch, Bethesda, MD 20892 USA

[2] Univ Texas, Dept Mol Genet & Microbiol, Austin, TX 78712 USA

来源：

NATURE | 2006年 / 439卷 / 7075期

关键词：

D O I：

10.1038/439406a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A double-stranded break in DNA can profoundly destabilize a cell's genome. But how does the cell recognize the damage and halt division until it can be fixed? The answer lies in the proteins that package and unravel DNA.

引用

页码：406 / 407

页数：2

共 13 条

[1] Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks [J].

Celeste, A ;

Fernandez-Capetillo, O ;

Kruhlak, MJ ;

Pilch, DR ;

Staudt, DW ;

Lee, A ;

Bonner, RF ;

Bonner, WM ;

Nussenzweig, A .

NATURE CELL BIOLOGY, 2003, 5 (07) :675-U51

[2] γ-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair [J].

Chowdhury, D ;

Keogh, MC ;

Ishii, H ;

Peterson, CL ;

Buratowski, S ;

Lieberman, J .

MOLECULAR CELL, 2005, 20 (05) :801-809

[3] Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites [J].

Downs, JA ;

Allard, S ;

Jobin-Robitaille, O ;

Javaheri, A ;

Auger, A ;

Bouchard, N ;

Kron, SJ ;

Jackson, SP ;

Côté, J .

MOLECULAR CELL, 2004, 16 (06) :979-990

[4] H2AX: the histone guardian of the genome [J].

Fernandez-Capetillo, O ;

Lee, A ;

Nussenzweig, M ;

Nussenzweig, A .

DNA REPAIR, 2004, 3 (8-9) :959-967

[5] A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery [J].

Keogh, MC ;

Kim, JA ;

Downey, M ;

Fillingham, J ;

Chowdhury, D ;

Harrison, JC ;

Onishi, M ;

Datta, N ;

Galicia, S ;

Emili, A ;

Lieberman, J ;

Shen, XT ;

Buratowski, S ;

Haber, JE ;

Durocher, D ;

Greenblatt, JF ;

Krogan, NJ .

NATURE, 2006, 439 (7075) :497-501

[6] Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions [J].

Kusch, T ;

Florens, L ;

MacDonald, WH ;

Swanson, SK ;

Glaser, RL ;

Yates, JR ;

Abmayr, SM ;

Washburn, MP ;

Workman, JL .

SCIENCE, 2004, 306 (5704) :2084-2087

[7] INO80 and γ-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair [J].

Morrison, AJ ;

Highland, J ;

Krogan, NJ ;

Arbel-Eden, A ;

Greenblatt, JF ;

Haber, JE ;

Shen, XT .

CELL, 2004, 119 (06) :767-775

[8] Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks [J].

Murr, R ;

Loizou, JI ;

Yang, YG ;

Cuenin, C ;

Li, H ;

Wang, ZQ ;

Herceg, Z .

NATURE CELL BIOLOGY, 2006, 8 (01) :91-U36

[9] DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139 [J].

Rogakou, EP ;

Pilch, DR ;

Orr, AH ;

Ivanova, VS ;

Bonner, WM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (10) :5858-5868

[10] Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break [J].

Shroff, R ;

Arbel-Eden, A ;

Pilch, D ;

Ira, G ;

Bonner, WM ;

Petrini, JH ;

Haber, JE ;

Lichten, M .

CURRENT BIOLOGY, 2004, 14 (19) :1703-1711

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