Sp1 is required for prolactin activation of the interferon regulatory factor-1 gene

被引：15
|
作者：
McAlexander, MB
Yu-Lee, L
机构：
[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA
[2] Baylor Coll Med, Dept Immunol, Houston, TX 77030 USA
[3] Baylor Coll Med, Dept Med, Houston, TX 77030 USA
来源：
MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2001年 / 184卷 / 1-2期
关键词：
Sp1; Stat1; interferon regulatory factor-1; prolactin; run-on transcription;
D O I：
10.1016/S0303-7207(01)00593-7
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Transcription of the interferon regulatory factor-1 gene (IRF-1) is induced in a biphasic manner (G1 and G1/S phase) in Nb2 T cells in response to prolactin (PRL) stimulation. Signal transducer and activator of transcription 1 (Stat1) is required for PRL activation of the IRF-1 promoter. Mutation of a -200 bp Sp1 site in the IRF-1 promoter results in a loss of GI but not G1/S IRF-1 transcriptional activity in response to PRL. These studies illustrate that the temporal transcription of the IRF-1 gene is mediated by not only Stat1 but also Sp1 in response to PRL stimulation. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：135 / 141
页数：7
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