Safety and efficacy of vismodegib in relapsed/refractory acute myeloid leukaemia: results of a phase Ib trial

被引：20

作者：

Bixby, Dale ^{[1
]}

Noppeney, Richard ^{[2
]}

Lin, Tara L. ^{[3
]}

Cortes, Jorge ^{[4
]}

Krauter, Juergen ^{[5
]}

Yee, Karen ^{[6
]}

Medeiros, Bruno C. ^{[7
]}

Kraemer, Alwin ^{[8
,9
]}

Assouline, Sarit ^{[10
]}

Fiedler, Walter ^{[11
]}

Dimier, Natalie ^{[12
]}

Simmons, Brian P. ^{[13
]}

Riehl, Todd ^{[13
]}

Colburn, Dawn ^{[13
]}

机构：

[1] Univ Michigan, Div Hematol & Med Oncol, Ann Arbor, MI 48109 USA

[2] Univ Klinikum Essen, Klin Hamatol, Essen, Germany

[3] Univ Kansas, Ctr Canc, Div Hematol Malignancies & Cellular Therapeut, Kansas City, KS USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Leukemia, Div Canc Med, Houston, TX USA

[5] Klinikum Braunschweig, Dept Haematol & Oncol, Braunschweig, Germany

[6] Princess Margaret Canc Ctr, Dept Haematol & Oncol, Toronto, ON, Canada

[7] Stanford Univ, Dept Hematol, Stanford, CA 94305 USA

[8] German Canc Res Ctr, Clin Cooperat Unit Mol Haematol Oncol, Heidelberg, Germany

[9] Heidelberg Univ, Dept Internal Med 5, Heidelberg, Germany

[10] Jewish Gen Hosp, Dept Oncol, Montreal, PQ, Canada

[11] Univ Med Ctr Hamburg Eppendorf, Dept Haematol, Hamburg, Germany

[12] Roche Prod Ltd, Biostat, Welwyn Garden City, Herts, England

[13] Genentech Inc, Prod Dev Oncol, San Francisco, CA 94080 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2019年 / 185卷 / 03期

关键词：

Hedgehog signalling; vismodegib; leukaemia; stem cells; MALIGNANCIES;

D O I：

10.1111/bjh.15571

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：595 / 598

页数：4

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