The first total synthesis of iPF4α-VI and its deuterated analog

被引：16
作者：
Kim, SJ
Lawson, JA
Praticò, D
FitzGerald, GA
Rokach, J
机构：
[1] Florida Inst Technol, Claude Pepper Inst, Melbourne, FL 32901 USA
[2] Florida Inst Technol, Dept Chem, Melbourne, FL 32901 USA
[3] Univ Penn, Ctr Expt Therapeut, Philadelphia, PA 19104 USA
来源：
TETRAHEDRON LETTERS | 2002年 / 43卷 / 15期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
isoprostanes; iP; arachidonic acid; AA; docosahexaenoic acid; DHA; iPF(4x)-VI; d(4)-iPF(4x)-VI;
D O I：
10.1016/S0040-4039(02)00398-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The total and stereospecific syntheses of iPF(4alpha)-VI and d(4)-iPF(4alpha)-VI have been accomplished, iPF(4alpha)-VI is a docosahexanenoic acid (DHA)-derived isoprostane. DHA is the most abundant polyunsaturated fatty acid in the brain. Different synthetic designs have been used for the two syntheses. In the d(4)-iPF(4alpha)-VI design, the deuterated part of the molecule has introduced last in the synthesis. (C) 2002 Elsevier Science Ltd. All rights reserved.
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收藏
页码：2801 / 2805
页数：5
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