Tumor suppressor functions of BNIP3 and mitophagy

被引：115

作者：

Chourasia, Aparajita H. ^{[1
,2
]}

Macleod, Kay F. ^{[1
,2
]}

机构：

[1] Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA

[2] Univ Chicago, Comm Canc Biol, Chicago, IL 60637 USA

来源：

AUTOPHAGY | 2015年 / 11卷 / 10期

关键词：

BNIP3; cancer; hypoxia; HIF-1; mitophagy; mitochondrial dysfunction; ROS; Warburg effect;

D O I：

10.1080/15548627.2015.1085136

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

There is a growing realization that tumor cells rely on healthy mitochondria to promote their growth under changing microenvironmental stresses and do so by dynamically modulating both their mitochondrial mass and state of mitochondrial fusion. Our recent work adds to this appreciation by showing that the mitophagy receptor BNIP3 functions as a tumor suppressor in mammary tumorigenesis and also as a prognostic indicator of progression to metastasis in certain sub-types of human breast cancer.

引用

页码：1937 / 1938

页数：2