Comprehensive Analysis of Differentially Expressed lncRNAs in the Perivascular Adipose Tissue of Patients with Coronary Heart Disease

被引：0
|
作者：
Xie, Xianwei [1 ]
Wang, Sunying [1 ]
Rao, Jingyi [1 ]
Xue, Jing [2 ]
Lin, Kaiyang [1 ,3 ,4 ]
Lin, Na [1 ,3 ]
Li, Ke [2 ]
Wu, Shilun [5 ]
Liang, Wenjia [1 ]
Guo, Yansong [1 ,3 ,4 ]
机构：
[1] Fujian Med Univ, Fujian Prov Hosp, Shengli Clin Med Coll, Dept Cardiol, Fuzhou 350013, Fujian, Peoples R China
[2] Capital Med Univ, Beijing Tiantan Hosp, China Natl Clin Res Ctr Neurol Dis, Adv Innovat Ctr Human Brain Protect, Beijing 100070, Peoples R China
[3] Fujian Clin Med Res Ctr Cardiovasc Dis, Fujian Prov Ctr Geriatr, Fujian Prov Key Lab Cardiovasc Dis, Fuzhou 350000, Fujian, Peoples R China
[4] Fujian Heart Failure Ctr Alliance, Fuzhou 350000, Fujian, Peoples R China
[5] Capital Med Univ, Beijing Chaoyang Hosp, Dept Hepatobiliary Surg, Beijing 100043, Peoples R China
来源：
REVIEWS IN CARDIOVASCULAR MEDICINE | 2022年 / 23卷 / 10期
基金：
中国国家自然科学基金;
关键词：
coronary heart disease; Atherosclerosis; perivascular adipose tissue; immune system; long non-coding RNA; competing endogenous RNA; LONG NONCODING RNAS; CARDIOVASCULAR-DISEASES; ARTERY; CELL; DYSFUNCTION; BIOMARKERS; HEALTH;
D O I：
10.31083/j.rcm2310341
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background: Coronary heart disease is a highly prevalent inflammatory disease caused by coronary atherosclerosis. Numerous studies have revealed that perivascular adipose tissue is closely associated with atherosclerosis. Here, we conducted a comprehensive analysis of long non-coding RNAs and mRNAs differentially expressed in perivascular adipose tissue in patients with coronary heart disease. Methods: We conducted Gene Ontology term and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the differentially expressed genes. Furthermore, single sample gene set enrichment analysis, immune infiltration analysis, and co-expression analysis of differentially expressed long non-coding RNAs and immune gene sets were performed. Finally, the starBase and miRTarBase databases were used to construct a competing endogenous RNA network. Results: The results show that aortic perivascular adipose tissue has higher inflammation and immune infiltration levels in patients with coronary heart disease. Dysregulated long non-coding RNAs may be related to immunity, inflammation, and hypoxia. Conclusions: The findings of this study provide new insights into atherosclerosis and coronary heart disease.
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页数：15
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