VE-cadherin at a glance

被引：36

作者：

Bravi, Luca ^{[1
]}

Dejana, Elisabetta ^{[1
,2
]}

Lampugnani, Maria Grazia ^{[1
,3
]}

机构：

[1] FIRC Inst Mol Oncol IFOM Fdn, I-20139 Milan, Italy

[2] Univ Milan, Dept Biosci, Sch Sci, Milan, Italy

[3] Mario Negri Inst Pharmacol Res, Milan, Italy

来源：

CELL AND TISSUE RESEARCH | 2014年 / 355卷 / 03期

基金：

欧洲研究理事会;

关键词：

VE-cadherin; Cell-to-cell junctions; Endothelium; Permeability; Angiogenesis; VASCULAR ENDOTHELIAL CADHERIN; CEREBRAL CAVERNOUS MALFORMATIONS; CELL-CELL CONTACTS; BETA-CATENIN; TYROSINE PHOSPHORYLATION; ALPHA-CATENIN; RHO-KINASE; JUNCTIONS; ASSOCIATION; ADHESION;

D O I：

10.1007/s00441-014-1843-7

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although being a monolayer the vascular endothelium controls fundamental vessel functions such as permeability, leukocyte extravasation and angiogenesis. The endothelial selective transmembrane constituent of adherens junctions, Vascular Endothelial- (VE-) cadherin plays a crucial role in the regulation of such activities. The signaling pathways controlled by VE-cadherin as well as the ones that regulate VE-cadherin activity start to be elucidated. This delineates a complex network of molecular and functional interactions that can be altered in pathologies.

引用

收藏

页码：515 / 522

页数：8

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