Individualized neuropathic pain therapy based on phenotyping: are we there yet?

被引：48
作者：
Forstenpointner, Julia [1 ]
Otto, Jan [1 ]
Baron, Ralf [1 ]
机构：
[1] Univ Hosp Schleswig Holstein, Div Neurol Pain Res & Therapy, Dept Neurol, Campus Kiel, D-24105 Kiel, Germany
来源：
PAIN | 2018年 / 159卷 / 03期
关键词：
Chronic pain; Sensory phenotype; Mechanism-based treatment; Human pain model; Quantitative sensory testing; Patient-reported outcome; DOUBLE-BLIND; POSTHERPETIC NEURALGIA; SENSORY PROFILES; EFFICACY; MODULATION; MECHANISMS; TAPENTADOL; LIDOCAINE; CAPSAICIN; SYMPTOMS;
D O I：
10.1097/j.pain.0000000000001088
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
Patients with the same neuropathic pain disorder may have completely different sensory signs and symptoms yet receive the same medicinal treatment. New concepts suggest that patient stratification according to their pain mechanisms, reflected in their sensory phenotype, could be promising to implement an individualized therapy in neuropathic pain. Retrospective classification of patients according to their sensory phenotype showed predictive validity and reliability for treatment response in certain subgroups of patients. Recent prospective studies using stratification based on sensory phenotypes confirm this concept. In this article, we review the recent accomplishments towards an individualized pharmacological treatment of neuropathic pain.
引用
收藏
页码：569 / 575
页数：7
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