Synthesis of 2,3-dimethoxy-7-methyl-7,12-dihydro-6H-[1]benzofuro-[2,3-c]-[1]-benzazepin-6,12-dione.

被引:4
作者
Jackson, YA [1 ]
Marriott, KSC [1 ]
机构
[1] Univ W Indies, Dept Chem, Kingston 7, Jamaica
关键词
PPA; cyclization; benzoxazinone; benzofuro-[2,3-c]-[1]-benzazepin-6,12-dione;
D O I
10.3390/70300353
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Treatment of 5,6-dimethoxy-2-(methylphenylcarbamoyl)-benzofuran-3carboxylic acid with PPA yielded 2,3-dimethoxy-7-methyl-7,12-dihydro-6H-[1]benzofuro-[2,3-c]-[1]-benzazepin-6,12-dione. The analogous 2-[(5,6-dimethoxybenzofuran-2-carbonyl)methylamino]benzoic acid was resistant to cyclization, whereas 2-[(6-methoxybenzofuran-2-carbonyl)-amino]benzoic acid underwent cyclization. to the corresponding 3, 1-benzoxazin-4-one.
引用
收藏
页码:353 / 362
页数:10
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