Calcium-Mediated Secondary Cross-Linking of Bisphosphonated Oligo(poly(ethylene glycol) Fumarate) Hydrogels

被引：10

作者：

Nejadnik, M. Reza ^{[1
]}

Yang, Xia ^{[2
]}

Mimura, Tokio ^{[3
]}

Birgani, Zeinab Tahmasebi ^{[4
]}

Habibovic, Pamela ^{[4
]}

Itatani, Kiyoshi ^{[3
]}

Jansen, John A. ^{[1
]}

Hilborn, Jons ^{[2
]}

Ossipov, Dmitri ^{[2
]}

Mikos, Antonios G. ^{[5
]}

Leeuwenburgh, Sander C. G. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen Med Ctr, Dept Biomat, Nijmegen, Netherlands

[2] Uppsala Univ, Dept Chem Mat, Angstrom Lab, Uppsala, Sweden

[3] Sophia Univ, Fac Sci & Engn, Dept Mat & Life Sci, Tokyo 102, Japan

[4] Univ Twente, Dept Tissue Regenerat, MIRA Inst Biomed Technol & Tech Med, NL-7500 AE Enschede, Netherlands

[5] Rice Univ, Dept Bioengn, Houston, TX USA

来源：

MACROMOLECULAR BIOSCIENCE | 2013年 / 13卷 / 10期

关键词：

SURFACE MODIFICATION; POLYMER NETWORKS; NANOPARTICLES; METALLOPOLYMERS; IONS;

D O I：

10.1002/mabi.201300117

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study demonstrates, for the first time, that synthetic PEG-based hydrogels can be cross-linked reversibly by calcium upon functionalization of the polymer backbone with bisphosphonate groups (BPs) that allow for the formation of strong coordination bonds with divalent metal ions such as Mg2+ and Ca2+. More specifically, it is shown that BP-functionalized hydrogels can be shaped by providing calcium ions as reversible physical cross-linkers. BP-functionalized PEG-based hydrogels allow the formation of strong coordination cross-links in the presence of divalent metal ions such as Mg2+ and Ca2+. Therefore, BP-functionalized hydrogels can be shaped by providing calcium ions as reversible physical cross-linkers. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1308 / 1313

页数：6

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