GDNF is a chemoattractant factor for neuronal precursor cells in the rostral migratory stream

被引：113

作者：

Paratcha, G ^{[1
]}

Ibáñez, CF ^{[1
]}

Ledda, F ^{[1
]}

机构：

[1] Karolinska Inst, Dept Neurosci, Div Mol Neurobiol, S-17177 Stockholm, Sweden

来源：

MOLECULAR AND CELLULAR NEUROSCIENCE | 2006年 / 31卷 / 03期

关键词：

GDNF; chemoattraction; neuronal precursors; rostral migratory stream; NCAM;

D O I：

10.1016/j.mcn.2005.11.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Olfactory bulb (OB) interneurous are generated from neuroblast cells derived from the anterior subventricular zone (SVZa) of the forebrain. The mechanisms guiding the rostral migration of these neuronal precursors are not well understood. Here, we show that glial cell line-derived neurotrophic factor (GDNF) is produced in the olfactory bulb but distributed along the rostral migratory stream (RMS) in a pattern concordant with the expression of its GPI-anchored receptor GFR alpha 1. We demonstrate that GDNF is a chemoattractant factor for PMS-derived neuronal precursors, but not for SVZa neuroblast cells. In agreement with this, GDNF increased Cyclin-dependent kinase 5 (Cdk5) activity in RMS cells, a kinase critically involved in neuronal migration and guidance. GDNF-mediated cell chemoattraction was abrogated in RMS explants treated with the Cdk5 inhibitor Roscovitine as well as in RMS explants isolated from Ncam mutant mice. Chemical cross-linking assays showed that I-125-GDNF is able to interact directly with NCAM in RMS-derived cells. Taken together, these data demonstrate that GDNF is a direct chemoattractant factor for neuroblast cells migrating along the RMS and support the participation of NCAM during this guidance process. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：505 / 514

页数：10

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