Rational approaches to the treatment of hypertension: drug therapy-monotherapy, combination, or fixed-dose combination?

被引：13

作者：

Canbakan, Basol ^{[1
]}

机构：

[1] Ankara Numune Training & Res Hosp, TR-06100 Ankara, Turkey

来源：

KIDNEY INTERNATIONAL SUPPLEMENTS | 2013年 / 3卷 / 04期

关键词：

combination therapy; hypertension; treatment; HIGH-RISK; HYDROCHLOROTHIAZIDE;

D O I：

10.1038/kisup.2013.75

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Blood pressure (BP) control is inadequate worldwide. Many clinical trials suggest that BP is not satisfactorily controlled using monotherapy in most patients. Free drug or fixed-dose combinations are other therapeutic options. The advantages and disadvantages for different treatment approaches are discussed in this review.

引用

页码：349 / 351

页数：3

共 10 条

[1]

Altun L, 2005, J HYPERTENS, V23, P1817

[2] Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE):: a randomised trial against atenolol [J].

Dahlöf, B ;

Devereux, RB ;

Kjeldsen, SE ;

Julius, S ;

Beevers, G ;

de Faire, U ;

Fyhrquist, F ;

Ibsen, H ;

Kristiansson, K ;

Lederballe-Pedersen, O ;

Lindholm, LH ;

Nieminen, MS ;

Omvik, P ;

Oparil, S ;

Wedel, H .

LANCET, 2002, 359 (9311) :995-1003

[3]

Furberg CD, 2002, JAMA-J AM MED ASSOC, V288, P2981

[4] Initial Combination Therapy Reduces the Risk of Cardiovascular Events in Hypertensive Patients A Matched Cohort Study [J].

Gradman, Alan H. ;

Parise, Helene ;

Lefebvre, Patrick ;

Falvey, Heather ;

Lafeuille, Marie-Helene ;

Duh, Mei Sheng .

HYPERTENSION, 2013, 61 (02) :309-318

[5] Compliance, Safety, and Effectiveness of Fixed-Dose Combinations of Antihypertensive Agents A Meta-Analysis [J].

Gupta, Ajay K. ;

Arshad, Shazia ;

Poulter, Neil R. .

HYPERTENSION, 2010, 55 (02) :399-407

[6] Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension in High-Risk Patients [J].

Jamerson, Kenneth ;

Weber, Michael A. ;

Bakris, George L. ;

Dahlof, Bjorn ;

Pitt, Bertram ;

Shi, Victor ;

Hester, Allen ;

Gupte, Jitendra ;

Gatlin, Marjorie ;

Velazquez, Eric J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (23) :2417-2428

[7] Blood pressure control and improved cardiovascular outcomes in the international verapamil SR-trandolapril study [J].

Mancia, Giuseppe ;

Messerli, Franz ;

Bakris, George ;

Zhou, Qian ;

Champion, Annette ;

Pepine, Carl J. .

HYPERTENSION, 2007, 50 (02) :299-305

[8] Combination Therapy Versus Monotherapy in Reducing Blood Pressure: Meta-analysis on 11,000 Participants from 42 Trials [J].

Wald, David S. ;

Law, Malcolm ;

Morris, Joan K. ;

Bestwick, Jonathan P. ;

Wald, Nicholas J. .

AMERICAN JOURNAL OF MEDICINE, 2009, 122 (03) :290-300

[9] Time to achieve blood-pressure goal: Influence of dose of valsartan monotherapy and valsartan and hydrochlorothiazide combination therapy [J].

Weir, Matthew R. ;

Levy, Drew ;

Crikelair, Nora ;

Rocha, Ricardo ;

Meng, Xiangyi ;

Glazer, Robert .

AMERICAN JOURNAL OF HYPERTENSION, 2007, 20 (07) :807-815

[10] Telmisartan, ramipril, or both in patients at high risk for vascular events [J].

Yusuf, Salim ;

Teo, Koon K. ;

Pogue, Janice ;

Dyal, Leanne ;

Copland, Ingrid ;

Schumacher, Helmut ;

Ingelheim, Boehringer ;

Dagenais, Gilles ;

Sleight, Peter ;

Anderson, Craig .

NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (15) :1547-1559

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