Diabetic kidney disease and immune modulation

被引：64

作者：

Hickey, Fionnuala B. ^{[1
,2
]}

Martin, Finian ^{[1
,3
]}

机构：

[1] Univ Coll Dublin, UCD Conway Inst, UCD Diabet Complicat Res Ctr, Dublin 4, Ireland

[2] Univ Coll Dublin, Sch Med & Med Sci, Dublin 4, Ireland

[3] Univ Coll Dublin, Sch Biomol & Biomed Sci, Dublin 4, Ireland

来源：

CURRENT OPINION IN PHARMACOLOGY | 2013年 / 13卷 / 04期

基金：

爱尔兰科学基金会;

关键词：

TUMOR-NECROSIS-FACTOR; MONOCYTE CHEMOATTRACTANT PROTEIN-1; INTERCELLULAR-ADHESION MOLECULE-1; KAPPA-B ACTIVATION; STAGE RENAL-FAILURE; C-REACTIVE PROTEIN; FACTOR-ALPHA; MAST-CELLS; TNF-ALPHA; T-LYMPHOCYTES;

D O I：

10.1016/j.coph.2013.05.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Immune modulation is now known to contribute to the development of glomerulosclerosis, tubulointerstitial fibrosis and end-stage renal disease in a large number of kidney diseases. Similarly, diabetic nephropathy is increasingly considered an inflammatory disease, with immune modulation being involved in both the development and progression of the disease. Infiltration of immune cells including macrophages, T cells, B cells and mast cells into the kidney has been reported. A number of pro-inflammatory cytokines and chemokines also play a major role in pathogenesis of diabetic nephropathy. Consequently, a variety of therapeutic strategies involving modulation of the immune response are currently being investigated in diabetic kidney disease.

引用

页码：602 / 612

页数：11

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