miRNA in clinical practice: Pancreatic cancer

被引：31
作者：
Humeau, Marine [1 ,2 ,3 ]
Torrisani, Jerome [1 ,2 ]
Cordelier, Pierre [1 ,2 ]
机构：
[1] INSERM, Ctr Rech Cancerol Toulouse, UMR1037, F-31432 Toulouse 04, France
[2] Univ Toulouse 3, F-31062 Toulouse, France
[3] CHU Toulouse, Serv Chirurg Digest, Toulouse, France
来源：
CLINICAL BIOCHEMISTRY | 2013年 / 46卷 / 10-11期
关键词：
miRNA; Biomarkers; Pancreatic cancer; MICRORNA; EXPRESSION; ADENOCARCINOMA; DIAGNOSIS; CELLS; SERUM; PROLIFERATION; SIGNATURE; BIOMARKER; PATTERNS;
D O I：
10.1016/j.clinbiochem.2013.03.019
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
To date, pancreatic cancer (PDAC) can't be diagnosed early. Consequently, a majority of patient (80%) display an advanced disease that results in a low resection rate leading to an overall median survival of 4 to 6 months. Accordingly, robust markers for the early diagnosis and prognosis of pancreatic cancer, or markers indicative of survival and/or metastatic disease are desperately needed to help alleviate the dismal prognosis of this disease. In this chapter, we review the translational studies demonstrating that miRNAs, alone or in combination, may soon translate into clinical applications as long-awaited screening tools for PDAC. (C) 2013 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码：933 / 936
页数：4
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