Revolution in mitochondrial medicine

被引：61

作者：

Larsson, NG ^{[1
]}

Luft, R ^{[1
]}

机构：

[1] Karolinska Hosp, Dept Mol Med, Rolf Luft Res Ctr, S-17176 Stockholm, Sweden

来源：

FEBS LETTERS | 1999年 / 455卷 / 03期

关键词：

mitochondrial dysfunction; nuclear gene mutation; ageing; animal model;

D O I：

10.1016/S0014-5793(99)00854-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A revolution in chemical pathology occurred about 40 years ago with the discovery of a patient with mitochondrial dysfunction. The field of mitochondrial medicine has experienced explosive growth during the last decade. More than 50 mtDNA mutations and several nuclear gene mutations have been identified in affected patients. The recent development of animal models mill continue the revolution in mitochondrial medicine by facilitating in depth studies of the molecular pathogenesis and development of novel drug and gene therapy strategies for mitochondrial dysfunction, As me enter the next millennium, we can expect mitochondrial medicine to remain a dynamic and rapidly developing field. (C) 1999 Federation of European Biochemical Societies.

引用

页码：199 / 202

页数：4

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