共 20 条
Treosulfan/fludarabine as an allogeneic hematopoietic stem cell transplant conditioning regimen for high-risk patients
被引:21
作者:

Baronciani, Donatella
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机构:
Osped Oncol Armando Businco, Unita Operat Ematol, I-09121 Cagliari, Italy
Osped Oncol Armando Businco, Ctr Trapianti Wilma Deplano, I-09121 Cagliari, Italy Osped Oncol Armando Businco, Unita Operat Ematol, I-09121 Cagliari, Italy

Rambaldi, Alessandro
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机构:
Osped Riuniti Bergamo, UO Ematol & Ctr Trapianti, Bergamo, Italy Osped Oncol Armando Businco, Unita Operat Ematol, I-09121 Cagliari, Italy

Iori, Anna Paola
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机构:
Univ Roma La Sapienza, Ist Ematol, Rome, Italy Osped Oncol Armando Businco, Unita Operat Ematol, I-09121 Cagliari, Italy

Di Bartolomeo, Paolo
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机构:
Osped Civile Pescara, UO Ematol & Ctr Trapianti, Pescara, Italy Osped Oncol Armando Businco, Unita Operat Ematol, I-09121 Cagliari, Italy

Pilo, Federica
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机构:
Osped Oncol Armando Businco, Unita Operat Ematol, I-09121 Cagliari, Italy
Osped Oncol Armando Businco, Ctr Trapianti Wilma Deplano, I-09121 Cagliari, Italy Osped Oncol Armando Businco, Unita Operat Ematol, I-09121 Cagliari, Italy

Pettinau, Martina
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机构:
Osped Oncol Armando Businco, Unita Operat Ematol, I-09121 Cagliari, Italy
Osped Oncol Armando Businco, Ctr Trapianti Wilma Deplano, I-09121 Cagliari, Italy Osped Oncol Armando Businco, Unita Operat Ematol, I-09121 Cagliari, Italy

Depau, Cristina
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Osped Oncol Armando Businco, Unita Operat Ematol, I-09121 Cagliari, Italy
Osped Oncol Armando Businco, Ctr Trapianti Wilma Deplano, I-09121 Cagliari, Italy Osped Oncol Armando Businco, Unita Operat Ematol, I-09121 Cagliari, Italy

Mico, Caterina
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机构:
Osped Riuniti Bergamo, UO Ematol & Ctr Trapianti, Bergamo, Italy Osped Oncol Armando Businco, Unita Operat Ematol, I-09121 Cagliari, Italy

Santarone, Stella
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h-index: 0
机构:
Osped Civile Pescara, UO Ematol & Ctr Trapianti, Pescara, Italy Osped Oncol Armando Businco, Unita Operat Ematol, I-09121 Cagliari, Italy

Angelucci, Emanuele
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h-index: 0
机构:
Osped Oncol Armando Businco, Unita Operat Ematol, I-09121 Cagliari, Italy
Osped Oncol Armando Businco, Ctr Trapianti Wilma Deplano, I-09121 Cagliari, Italy Osped Oncol Armando Businco, Unita Operat Ematol, I-09121 Cagliari, Italy
机构:
[1] Osped Oncol Armando Businco, Unita Operat Ematol, I-09121 Cagliari, Italy
[2] Osped Oncol Armando Businco, Ctr Trapianti Wilma Deplano, I-09121 Cagliari, Italy
[3] Osped Riuniti Bergamo, UO Ematol & Ctr Trapianti, Bergamo, Italy
[4] Univ Roma La Sapienza, Ist Ematol, Rome, Italy
[5] Osped Civile Pescara, UO Ematol & Ctr Trapianti, Pescara, Italy
关键词:
D O I:
10.1002/ajh.21240
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
In years, new conditioning regimens have been explored in patients not eligible for conventional transplant with the aim to reduce transplant-related mortality. In a phase II multicentric prospective trial, we investigated the safety and feasibility of the treosulfan-fludarabine combination prior to allogeneic hematopoietic stem cell transplant in patients with various hematological malignancies not eligible for conventional regimens because of previous intensive treatment, older age, and comorbidities. Forty-six consecutive patients, median age 48 years (range 17-69), were enrolled. Sixteen of them were in complete remission, and 20 had a HSCT comorbidity index >= 1. Forty-four patients had regular and sustained engraftment, and 39 out of 40 evaluable patients developed complete chimerism. Nonhematological toxicity was limited. Risk of transplant-related mortality was 9% (95% CI, 2-17%) at day +100 and plotted at 15% (95% CI, 7-22%) after 7 months. The estimated overall survival and progression-free survival with a median follow-up of 20 months were 51% and 38%, respectively. The estimated 30 months progression-free survival for patients transplanted in remission was 56%. The treosulfan-fludarabine combination is a reduced-toxicity but myeloablative regimen that can be proposed to patients not fitting criteria for conventional transplant regimens. Longer follow-up and further prospective studies are necessary to evaluate this regimen.
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页码:717 / 720
页数:4
相关论文
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机构: Univ Magdeburg, D-39106 Magdeburg, Germany

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h-index: 0
机构: Univ Magdeburg, D-39106 Magdeburg, Germany

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h-index: 0
机构: Univ Magdeburg, D-39106 Magdeburg, Germany

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机构: Univ Magdeburg, D-39106 Magdeburg, Germany

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机构: Univ Magdeburg, D-39106 Magdeburg, Germany

Heim, M
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h-index: 0
机构: Univ Magdeburg, D-39106 Magdeburg, Germany

Freund, M
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机构: Univ Magdeburg, D-39106 Magdeburg, Germany

Casper, J
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机构: Univ Magdeburg, D-39106 Magdeburg, Germany
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h-index: 0
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Vogelsang, G
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h-index: 0
机构: Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA

Flowers, MED
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h-index: 0
机构: Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA