Validation of the Pancreas Donor Risk Index for use in a UK population

被引：28
作者：
Mittal, Shruti [1 ,2 ]
Lee, Fang Jann [1 ]
Bradbury, Lisa [3 ]
Collett, David [3 ]
Reddy, Srikanth [1 ]
Sinha, Sanjay [1 ]
Sharples, Edward [1 ]
Ploeg, Rutger J. [1 ]
Friend, Peter J. [1 ,2 ,4 ]
Vaidya, Anil [1 ]
机构：
[1] Oxford Univ Hosp NHS Trust, Oxford Transplant Ctr, Oxford, England
[2] Univ Oxford, Nuffield Dept Surg Sci, Oxford, England
[3] NHS Blood & Transplant, Bristol, Avon, England
[4] NIHR Biomed Res Ctr, Oxford, England
来源：
TRANSPLANT INTERNATIONAL | 2015年 / 28卷 / 09期
关键词：
pancreas transplant; graft survival; risk; predictor; GRAFT-SURVIVAL; KIDNEY TRANSPLANTATION; SUITABILITY SCORE; OUTCOMES; QUALITY;
D O I：
10.1111/tri.12563
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Pancreas graft failure rates remain substantial. The PDRI can be used at the time of organ offering, to predict one-year graft survival. This study aimed to validate the PDRI for a UK population. Data for 1021 pancreas transplants were retrieved from a national database for all pancreas transplants. Cases were categorized by PDRI quartile and compared for death-censored graft survival. Significant differences were observed between the UK and US cohorts. The PDRI accurately discriminated graft survival for SPK and was associated with a hazard ratio of 1.52 (P=0.009) in this group. However, in the PTA and PAK groups, no association between PDRI quartile and graft survival was observed. This is the largest study to validate the PDRI in a European cohort and has shown for the first time that the PDRI can be used as a tool to predict graft survival in SPK transplantation, but not PTA or PAK transplantation.
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收藏
页码：1028 / 1033
页数：6
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