Bevacizumab alleviates radiation-induced brain necrosis: A report of four cases

被引:8
作者
Li Xiang-Pan [1 ]
Chu Yuxin [1 ]
Wu Xiao-Fei [2 ]
Li Na [1 ]
Xu Tang-Peng [1 ]
Xu Xiao-Tao [1 ]
Ruan Chang-Li [1 ]
Hu Wei-Guo [1 ]
Song Qi-Bin [1 ]
机构
[1] Wuhan Univ, Renmin Hosp, Dept Oncol, Wuhan 430072, Peoples R China
[2] Wuhan Gen Hosp, Chinese Peoples Liberat Army, Dept Neurol, Wuhan, Peoples R China
关键词
Bevacizumab; brain necrosis; radiation;
D O I
10.4103/0973-1482.140782
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
To analyze the therapeutic effect of bevacizumab on radiation-induced brain necrosis. Four radiation-induced brain necrosis patients, administered with bevacizumab at a dose of 7.5 mg/kg every 3 weeks, 2 times. One case of brain metastasis of lung cancer and one case of nasopharyngeal carcinoma with brain necrosis after radiotherapy. However, their physical signs disappeared after the treatment with bevacizumab. One case of brainstem lesion and one case of brain glioma patient showed a transient improvement in signs and symptoms after treatment with bevacizumab. Bevacizumab can significantly alleviate the radiation-induced brain edema, and can improve the symptoms successively.
引用
收藏
页码:485 / 487
页数:3
相关论文
共 11 条
  • [1] Managing the cognitive effects of brain tumor radiation therapy
    Butler Jr. J.M.
    Rapp S.R.
    Shaw E.G.
    [J]. Current Treatment Options in Oncology, 2006, 7 (6) : 517 - 523
  • [2] Bevacizumab Treatment for Symptomatic Radiation Necrosis Diagnosed by Amino Acid PET
    Furuse, Motomasa
    Nonoguchi, Naosuke
    Kawabata, Shinji
    Yoritsune, Erina
    Takahashi, Masatsugu
    Inomata, Taisuke
    Kuroiwa, Toshihiko
    Miyatake, Shin-Ichi
    [J]. JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2013, 43 (03) : 337 - 341
  • [3] Cerebral radiation necrosis
    Giglio, P
    Gilbert, MR
    [J]. NEUROLOGIST, 2003, 9 (04) : 180 - 188
  • [4] Effect of bevacizumab on radiation necrosis of the brain
    Gonzalez, Javier
    Kumar, Ashok J.
    Conrad, Charles A.
    Levin, Victor A.
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2007, 67 (02): : 323 - 326
  • [5] Exacerbation of Cerebral Radiation Necrosis by Bevacizumab
    Jeyaretna, Deva Sanjeeva
    Curry, William T., Jr.
    Batchelor, Tracy T.
    Stemmer-Rachamimov, Anat
    Plotkin, Scott R.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (07) : E159 - E162
  • [6] RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED TRIAL OF BEVACIZUMAB THERAPY FOR RADIATION NECROSIS OF THE CENTRAL NERVOUS SYSTEM
    Levin, Victor A.
    Bidaut, Luc
    Hou, Ping
    Kumar, Ashok J.
    Wefel, Jeffrey S.
    Bekele, B. Nebiyou
    Prabhu, Sujit
    Loghin, Monica
    Gilbert, Mark R.
    Jackson, Edward F.
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2011, 79 (05): : 1487 - 1495
  • [7] CEREBRAL RADIONECROSIS - INCIDENCE AND RISK IN RELATION TO DOSE, TIME, FRACTIONATION AND VOLUME
    MARKS, JE
    BAGLAN, RJ
    PRASSAD, SC
    BLANK, WF
    [J]. INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1981, 7 (02): : 243 - 252
  • [8] Drug Review: Safety and Efficacy of Bevacizumab for Glioblastoma and Other Brain Tumors
    Narita, Yoshitaka
    [J]. JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 2013, 43 (06) : 587 - 595
  • [9] Sadraei NH, 2013, AM J CLIN ONCOL
  • [10] Reversal of cerebral radiation necrosis with bevacizumab treatment in 17 Chinese patients
    Wang, Yang
    Pan, Li
    Sheng, Xiaofang
    Mao, Yin
    Yao, Yu
    Wang, Enmin
    Zhang, Nan
    Dai, Jiazhong
    [J]. EUROPEAN JOURNAL OF MEDICAL RESEARCH, 2012, 17