Bevacizumab alleviates radiation-induced brain necrosis: A report of four cases

被引：8

作者：

Li Xiang-Pan ^{[1
]}

Chu Yuxin ^{[1
]}

Wu Xiao-Fei ^{[2
]}

Li Na ^{[1
]}

Xu Tang-Peng ^{[1
]}

Xu Xiao-Tao ^{[1
]}

Ruan Chang-Li ^{[1
]}

Hu Wei-Guo ^{[1
]}

Song Qi-Bin ^{[1
]}

机构：

[1] Wuhan Univ, Renmin Hosp, Dept Oncol, Wuhan 430072, Peoples R China

[2] Wuhan Gen Hosp, Chinese Peoples Liberat Army, Dept Neurol, Wuhan, Peoples R China

来源：

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS | 2015年 / 11卷 / 02期

关键词：

Bevacizumab; brain necrosis; radiation;

D O I：

10.4103/0973-1482.140782

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To analyze the therapeutic effect of bevacizumab on radiation-induced brain necrosis. Four radiation-induced brain necrosis patients, administered with bevacizumab at a dose of 7.5 mg/kg every 3 weeks, 2 times. One case of brain metastasis of lung cancer and one case of nasopharyngeal carcinoma with brain necrosis after radiotherapy. However, their physical signs disappeared after the treatment with bevacizumab. One case of brainstem lesion and one case of brain glioma patient showed a transient improvement in signs and symptoms after treatment with bevacizumab. Bevacizumab can significantly alleviate the radiation-induced brain edema, and can improve the symptoms successively.

引用

页码：485 / 487

页数：3

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