Influence of chronic intermittent hypoxia on growth associated protein 43 expression in the hippocampus of young rats

被引：9

作者：

Chen, Yan ^{[1
]}

Zhao, Chunling ^{[1
]}

Zhang, Chunlai ^{[1
]}

Luo, Lirong ^{[2
]}

Yu, Guang ^{[1
]}

机构：

[1] Luzhou Med Coll, Dept Physiol, Luzhou 646000, Sichuan Provinc, Peoples R China

[2] Luzhou Med Coll, Funct Expt Ctr, Luzhou 646000, Sichuan Provinc, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2012年 / 7卷 / 16期

关键词：

chronic intermittent hypoxia; brain injury; growth associated protein 43; obstructive sleep apnea hypopnea syndrome; hippocampus; young rats; neural regeneration; OBSTRUCTIVE SLEEP-APNEA; CHILDREN; GAP-43; PLASTICITY; DISORDERS;

D O I：

10.3969/j.issn.1673-5374.2012.16.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This study aimed to explore the pathological change to hippocampal neurons and the expression of growth associated protein 43 in 21-day-old young rats following chronic intermittent hypoxia. Hematoxylin-eosin staining results showed varying degrees of degeneration and necrosis in hippocampal neurons depending on the modeling time. Immunohistochemistry revealed that growth associated protein 43 expression in young rats following chronic intermittent hypoxia decreased, but that levels were still higher than those of normal rats at each time point, especially 4 weeks after modeling. During 1-5 weeks after modeling, a slow growth in rat weight was observed. Experimental findings indicate that chronic intermittent hypoxia may induce growth dysfunction and necrosis of hippocampal neurons, as well as increase the expression of growth associated protein 43 in young rats.

引用

页码：1241 / 1246

页数：6

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