Concise and practical approach for the synthesis of honokiol, a neurotrophic agent

被引：6

作者：

Khan, P. Rasvan ^{[1
,2
]}

Mujawar, Taufiqueahmed ^{[1
,2
]}

Shekhar, P. ^{[1
,2
]}

Shankar, G. ^{[1
,2
]}

Reddy, B. V. Subba ^{[1
,2
]}

Subramanyam, Ravi ^{[1
,2
]}

机构：

[1] CSIR Indian Inst Chem Technol, Fluoro & Agrochem, Hyderabad 500007, India

[2] Colgate Palmol Technol Ctr, 909 River Rd, Piscataway, NJ USA

来源：

TETRAHEDRON LETTERS | 2020年 / 61卷 / 35期

关键词：

ortho-Lithiation; Claisen rearrangement; Suzuki cross-coupling; Honokiol; EFFICIENT SYNTHESIS; MAGNOLIA-OBOVATA; NEOLIGNANS; BARK;

D O I：

10.1016/j.tetlet.2020.152229

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An improved method has been developed for the synthesis of honokiol using a readily available p-bromophenol as a precursor. The key step involved in this method is ortho-lithiation facilitated by methoxymethyl ether (MOM). Other important steps are ortho-allyl phenyl ether Claisen rearrangement and a Suzuki coupling for the construction of biaryls. This method does not require pre-functionalization of aromatic ring with bromide for the generation of arylboronic acid. (C) 2020 Elsevier Ltd. All rights reserved.

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页数：2

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