Radiation-induced cardiac damage in early left breast cancer patients: Risk factors, biological mechanisms, radiobiology, and dosimetric constraints

被引：156
|
作者：
Sardaro, Angela [1 ]
Petruzzelli, Maria Fonte [2 ]
D'Errico, Maria Patrizia [3 ]
Grimaldi, Luca [4 ]
Pili, Giorgio [4 ]
Portaluri, Maurizio [2 ,5 ]
机构：
[1] Policlin Bari, Univ Inst Radiat Oncol, Bari, Italy
[2] A Perrino Hosp, Dept Radiotherapy, I-72100 Brindisi, Italy
[3] A Perrino Hosp, Dept Lab Med, I-72100 Brindisi, Italy
[4] A Perrino Hosp, Dept Phys Med, I-72100 Brindisi, Italy
[5] IFC CNR, Natl Res Council, Inst Clin Physiol, Pisa, Italy
来源：
RADIOTHERAPY AND ONCOLOGY | 2012年 / 103卷 / 02期
关键词：
Cardiac damage; Radiotherapy; Breast cancer; Dosimetric constraints; Biological parameters; INDUCED HEART-DISEASE; INFLAMMATORY PLAQUE PHENOTYPE; CARDIOVASCULAR MORTALITY; ADJUVANT RADIOTHERAPY; IONIZING-RADIATION; INDUCED ATHEROMATOSIS; CONSERVATIVE SURGERY; NATRIURETIC-PEPTIDE; RANDOMIZED-TRIAL; NORMAL TISSUE;
D O I：
10.1016/j.radonc.2012.02.008
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Today there is general awareness of the potential damage to the heart in left-sided (more than in right-sided) breast cancer radiotherapy (RT). Historical changes in tumor and heart doses are presented here along with the impact of different RT techniques and volumes. Individual and pharmacological risk factors are also examined with respect to radiation damage. The biological mechanisms of harm are only partially understood, such as the radiobiology of heart damage due to the presence of various radiosensitive structures and their topographic heterogeneity. Furthermore, individual variability may expose patients to higher or lower risks of late cardiac damage or death. Damage mechanisms and radiobiological characteristics in heart irradiation are presented in relation to dosimetric and biological parameters. (C) 2012 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 103 (2012) 133-142
引用
收藏
页码：133 / 142
页数：10
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