"Sulfolefin": a mixed sulfinamido-olefin ligand in enantioselective rhodium-catalyzed addition of arylboronic acids to trifluoromethyl ketones

被引:19
作者
Valdivia, Victoria [1 ,2 ]
Fernandez, Inmaculada [2 ]
Khiar, Noureddine [1 ]
机构
[1] Univ Seville, CSIC, Inst Invest Quim, Seville 41092, Spain
[2] Univ Seville, Fac Farm, Dept Quim Organ & Farmaceut, E-41012 Seville, Spain
关键词
CONSTRUCTION; RH; CHEMISTRY; REAGENTS;
D O I
10.1039/c3ob41888j
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Performing catalytic enantioselective carbon-carbon bond forming reactions, especially for the synthesis of tertiary carbinols, is one of the most challenging goals in modern asymmetric synthesis. Herein, we report an efficient enantioselective catalytic approach for the 1,2-addition of arylboronic acids to trifluoromethyl ketones affording tertiary trifluoromethyl-substituted alcohols with high yields and good enantioselectivities. The reported process uses as a catalyst precursor the shelf stable sulfinamido-olefin ligand 1, "sulfolefin", obtained on a multigram scale and in one step from a sugar derived sulfinate ester.
引用
收藏
页码:1211 / 1214
页数:4
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