The blood pressure effect and related plasma levels of flavan-3-ols in spontaneously hypertensive rats

被引：0
|
作者：
Quinones, Mar [1 ]
Margalef, Maria [2 ]
Arola-Arnal, Anna [2 ]
Muguerza, Begona [2 ,3 ]
Miguel, Marta [4 ]
Aleixandre, Amaya [1 ]
机构：
[1] U Complutense, Fac Med, Dept Farmacol, Madrid 28040, Spain
[2] Univ Rovira & Virgili, Dept Biochem & Biotechnol, Nutrigenom Grp, E-43007 Tarragona, Spain
[3] CEICS, TECNIO, CTNS, Reus, Spain
[4] CEI UAM CSIC, CSIC UAM, CIAL, Inst Investigac Ciencias Alimentac, Madrid, Spain
来源：
FOOD & FUNCTION | 2015年 / 6卷 / 11期
关键词：
RICH COCOA POWDER; NITRIC-OXIDE; ANTIOXIDANT CAPACITY; VASCULAR FUNCTION; RED WINE; METABOLITES; EPICATECHIN; POLYPHENOL; PROANTHOCYANIDIN; BIOAVAILABILITY;
D O I：
10.1039/c5fo00547g
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We studied the short-term antihypertensive effect of flavan-3-ols (-)-epicatechin, (+)-catechin and (-)-catechin, in spontaneously hypertensive rats (SHR). Plasma metabolites and the corresponding plasma antioxidant capacity were determined. All the assayed flavan-3-ols decreased systolic blood pressure (SBP) in SHR. Their antihypertensive effects were less pronounced than that of Captopril (50 mg kg(-1)) and were not shown in normotensive Wistar-Kyoto rats. 6 mg kg-1 (-)-epicatechin caused the maximum decrease in SBP. The maximum effects of the catechin monomers were observed post-administration of 0.5 mg kg(-1) of flavan-3-ols, (-)-catechin being the least effective among the three assayed compounds. Glucuronide and methyl glucuronide metabolites were obtained in the flavan-3-ol treated SHR, but it was not possible to relate the antihypertensive effect of the assayed flavan-3-ols with a concrete plasma metabolite or with their antioxidant effect. In conclusion, the studied flavan-3-ols could be responsible for the antihypertensive effect of cocoa products.
引用
收藏
页码：3479 / 3489
页数：11
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