Ruthenium-Catalyzed Enantioselective Propargylation of Indoles with Propargylic Alcohols

被引：32
|
作者：
Kanao, Keiichiro [1 ]
Matsuzawa, Hiroshi [1 ]
Miyake, Yoshihiro [1 ]
Nishibayashi, Yoshiaki [1 ]
机构：
[1] Univ Tokyo, Sch Engn, Inst Engn Innovat, Bunkyo Ku, Tokyo 1138656, Japan
来源：
SYNTHESIS-STUTTGART | 2008年 / 23期
关键词：
asymmetric synthesis; Friedel-Crafts alkylation; ruthenium; indoles; propargylic alcohols;
D O I：
10.1055/s-0028-1083217
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Ruthenium-catalyzed enantioselective propargylation of 1-(triisopropylsilyl)-1H-indoles with propargylic alcohols gives the corresponding beta-propargylated indoles in good yields with high enantioselectivity. Reactions with 1-(1-naphthyl)prop-2-yn-l-ol achieve the highest enantioselectivity (up to 95% ee).
引用
收藏
页码：3869 / 3873
页数：5
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