An in vitro study on the photosensitivity of 5-aminolevulinic acid conjugated gold nanoparticles

被引：34

作者：

Mohammadi, Zahra ^{[1
]}

Sazgarnia, Ameneh ^{[2
]}

Rajabi, Omid ^{[3
]}

Soudmand, Samaneh ^{[4
]}

Esmaily, Habibollah ^{[5
]}

Sadeghi, Hamid Reza ^{[4
]}

机构：

[1] Bobol Univ Med Sci, Dept & Res Ctr Med Phys, Babol Sar, Iran

[2] Mashhad Univ Med Sci, Med Phys Res Ctr, Mashhad, Iran

[3] Mashhad Univ Med Sci, Sch Pharm, Dept Med Chem, Mashhad, Iran

[4] Med Univ Mashhad, Med Phys Res Ctr, Mashhad, Iran

[5] Med Univ Mashhad, Dept Biostat, Mashhad, Iran

来源：

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY | 2013年 / 10卷 / 04期

关键词：

5-Aminolevulinic acid; Gold nanoparticle (GNP); Photodynamic therapy (PDT); Protoporphyrin IX (PpIX); Mel-Rm cell line; MEDIATED PHOTODYNAMIC THERAPY; CANCER; RADIATION; EFFICACY; MICE;

D O I：

10.1016/j.pdpdt.2013.03.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: In this study, the photosensitivity of 5-aminolevulinic acid (5-ALA) conjugated gold nanoparticles (conjugate) has been investigated on the MeL-Rm cell line. Methods: After culture and proliferation of the Mel-Rm cell line, cell toxicity and the suitable cell incubation time of the conjugate were determined. Photosensitivity of the conjugate and free 5-ALA was then studied in optical doses of 20, 40, 60 and 80J/cm(2) while tight irradiation was applied by a He-Ne laser. Results: A 4-h time interval was determined as the optimum incubation time for 5-ALA and the conjugate. PpIX induction into the cells showed a significant increase after incubation with the conjugate in comparison to 5-ALA alone. Also, the conjugate resulted in a two times higher cell death rate compared to free 5-ALA. Conclusion: The conjugate can be used as an appropriate delivery agent for 5-ALA and provide efficient cell destruction during PDT. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：382 / 388

页数：7

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