Structural vs Practical Identifiability in System Biology

被引：0
|
作者：
Saccomani, Maria Pia [1 ]
机构：
[1] Univ Padua, Dept Informat Engn, I-35131 Padua, Italy
来源：
PROCEEDINGS IWBBIO 2013: INTERNATIONAL WORK-CONFERENCE ON BIOINFORMATICS AND BIOMEDICAL ENGINEERING | 2013年
关键词：
system biology; differential equations model; structural identifiability; practical identifiability; parameter estimation; experiment design; GLOBAL IDENTIFIABILITY; NONLINEAR-SYSTEMS; PARAMETER IDENTIFIABILITY; MODELS;
D O I：
暂无
中图分类号：
TP39 [计算机的应用];
学科分类号：
081203 ; 0835 ;
摘要：
The relevance of model identifiability in system biology is well known. The aim of this paper is to discuss and possibly clarify the role and differences of two different methodologies of testing identifiability of models described by differential equations. One is called structural identifiability and does not require to use data collected in the experiment which, instead, data-based approaches do. The two methods are compared and evaluated in the identifiability analysis of a much quoted biological model, the core model of erythropoietin (Epo) and Epo receptor (EpoR) interaction.
引用
收藏
页码：305 / 313
页数：9
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