The dual role of the novel Wnt receptor tyrosine kinase, ROR2, in human carcinogenesis

被引：63
作者：
Ford, Caroline E.
Ma, Sean Si Qian
Quadir, Ashfaque
Ward, Robyn L.
机构：
[1] Univ New S Wales, Wnt Signaling & Metastasis Grp, Lowy Canc Res Ctr, Sydney, NSW 2052, Australia
[2] Univ New S Wales, Fac Med, Prince Wales Clin Sch, Sydney, NSW 2052, Australia
来源：
INTERNATIONAL JOURNAL OF CANCER | 2013年 / 133卷 / 04期
关键词：
ROR2; Wnt5a; Wnt signaling; cancer; metastasis; -catenin; CHRONIC LYMPHOCYTIC-LEUKEMIA; POTENTIAL THERAPEUTIC TARGET; BREAST-CANCER; SIGNALING PATHWAY; CELL MOTILITY; EXPRESSION; PROTEIN; CARCINOMA; DISTINCT; FAMILY;
D O I：
10.1002/ijc.27984
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The Wnt signaling pathway is involved in the development and progression of many human cancers, yet attempts to target the pathway therapeutically have been disappointing to date. The recent discovery that the ROR2 receptor tyrosine kinase (RTK) is a novel Wnt receptor provides the potential to target the non-canonical Wnt pathway for cancer treatments. As a member of the RTK superfamily of surface receptors ROR2 appears to possess dual roles as a tumor suppressor or activator depending on tumor type. This review will explore the dual role of ROR2 in tumorigenesis and provide an up to date analysis of current literature in this rapidly expanding field.
引用
收藏
页码：779 / 787
页数：9
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