HMGA2, MicroRNAs, and Stem Cell Aging

被引：118

作者：

Hammond, Scott M. ^{[1
,3
]}

Sharpless, Norman E. ^{[2
,3
]}

机构：

[1] Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Med & Genet, Chapel Hill, NC 27599 USA

[3] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

来源：

CELL | 2008年 / 135卷 / 06期

关键词：

D O I：

10.1016/j.cell.2008.11.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mammalian aging results from a replicative decline in the function of somatic stem cells and other self-renewing cells. Recent studies (Monzen et al., 2008; Nishino et al., 2008; Sanna et al., 2008; Weedon et al., 2008) link a chromatin-associated protein, HMGA2, to development, height, and mouse stem cell aging during late fetal development and young adulthood.

引用

页码：1013 / 1016

页数：4

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