CDC25A: A Rebel Within the CDC25 Phosphatases Family?

被引：24
作者：
Fernandez-Vidal, Anne [1 ]
Mazars, Anne [1 ]
Manenti, Stephane [1 ]
机构：
[1] CHU Purpan, Dept Oncogenese & Signalisat Cellules Hematopoiet, Ctr Physiopathol Toulouse Purpan, INSERM,U563 IFR30, F-31024 Toulouse 3, France
来源：
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY | 2008年 / 8卷 / 08期
关键词：
CDC25A phosphatase; cell cycle; proliferation; apoptosis; G1/S transition; oncogenesis;
D O I：
10.2174/187152008786847684
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
CDC25 dual specificity phosphatases activate the cyclin-dependent kinase complexes, allowing timely ordered progression through out the different phases of the eukaryotic cell cycle. In humans, there are three genes coding for the CDC25A, B and C proteins with both different and redundant specificities and regulations. The CDC25A member of this family acts during the G1 phase and at the G1/S transition by activating the CDK2/cyclin E and CDK2/cyclin A complexes, a function apparently not shared by the other members. In consequence, CDC25A is submitted to extra-cellular signals-dependent regulations involving in particular mitogenic signal transducers, and leading to modifications of its stability, its localization or its activity. In addition, CDC25A is up-regulated in various cancers, and the molecular mechanisms leading to this up-regulation are far from being understood. In this review, we will synthesize the current knowledge about CDC25A molecular regulations, and try to integrate these data in the cell proliferation and apoptotic functions described for the protein.
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收藏
页码：825 / 831
页数：7
相关论文
共 94 条
  • [1] Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation
    Bahassi, ELM
    Hennigan, RF
    Myer, DL
    Stambrook, PJ
    [J]. ONCOGENE, 2004, 23 (15) : 2658 - 2663
  • [2] Phosphorylation of human CDC25B phosphatase by CDK1-cyclin A triggers its proteasome-dependent degradation
    Baldin, V
    Cans, C
    Knibiehler, M
    Ducommun, B
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (52) : 32731 - 32734
  • [3] PKB/Akt phosphorylates the CDC25B phosphatase and regulates its intracellular localisation
    Baldin, V
    Theis-Febvre, N
    Benne, C
    Froment, C
    Cazales, M
    Burlet-Schiltz, O
    Ducommun, B
    [J]. BIOLOGY OF THE CELL, 2003, 95 (08) : 547 - 554
  • [4] The STAT3 transcription factor is a target for the Myc and riboblastoma proteins on the Cdc25A promoter
    Barré, B
    Vigneron, A
    Coqueret, O
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (16) : 15673 - 15681
  • [5] Cdc25A stability is controlled by the ubiquitin-proteasome pathway during cell cycle progression and terminal differentiation
    Bernardi, R
    Liebermann, DA
    Hoffman, B
    [J]. ONCOGENE, 2000, 19 (20) : 2447 - 2454
  • [6] Cdk2 knockout mice are viable
    Berthet, C
    Aleem, E
    Coppola, V
    Tessarollo, L
    Kaldis, P
    [J]. CURRENT BIOLOGY, 2003, 13 (20) : 1775 - 1785
  • [7] TGF-β-induced RhoA and p160ROCK activation is involved in the inhibition of Cdc25A with resultant cell-cycle arrest
    Bhowmick, NA
    Ghiassi, M
    Aakre, M
    Brown, K
    Singh, V
    Moses, HL
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (26) : 15548 - 15553
  • [8] Blomberg I, 1999, MOL CELL BIOL, V19, P6183
  • [9] Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis
    Busino, L
    Chiesa, M
    Draetta, GF
    Donzelli, M
    [J]. ONCOGENE, 2004, 23 (11) : 2050 - 2056
  • [10] Degradation of Cdc25A by β-TrCP during S phase and in response to DNA damage
    Busino, L
    Donzelli, M
    Chiesa, M
    Guardavaccaro, D
    Ganoth, D
    Dorrello, NV
    Hershko, A
    Pagano, M
    Draetta, GF
    [J]. NATURE, 2003, 426 (6962) : 87 - 91
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