Potent and selective azetidine-based dipeptidyl peptidase IV (DPP IV) inhibitors

被引:0
|
作者
Li, WX
Oliver, E
Rojas, C
Lauter, S
Thomas, B
Belyakov, S
机构
[1] Merck & Co Inc, Dept Med Chem, Rahway, NJ 07065 USA
[2] Merck & Co Inc, Dept Metab Disorders, Rahway, NJ 07065 USA
来源
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 229卷
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
207-MEDI
引用
收藏
页码:U145 / U146
页数:2
相关论文
共 50 条
  • [41] 4-cyanothiazolidides as very potent, stable inhibitors of dipeptidyl peptidase IV
    Ashworth, DM
    Atrash, B
    Baker, GR
    Baxter, AJ
    Jenkins, PD
    Jones, DM
    Szelke, M
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (22) : 2745 - 2748
  • [42] Dipeptidyl peptidase IV inhibitors for the treatment of diabetes
    Weber, AE
    JOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (17) : 4135 - 4141
  • [43] Suppression of arthritis by the inhibitors of dipeptidyl peptidase IV
    Tanaka, S
    Murakami, T
    Horikawa, H
    Sugiura, M
    Kawashima, K
    Sugita, T
    INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY, 1997, 19 (01): : 15 - 24
  • [44] Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors
    Caldwell, CG
    Chen, P
    He, JF
    Parmee, ER
    Leiting, B
    Marsilio, F
    Patel, RA
    Wu, JK
    Eiermann, GJ
    Petrov, A
    He, HB
    Lyons, KA
    Thornberry, NA
    Weber, AE
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (05) : 1265 - 1268
  • [45] Discovery of alogliptin: A potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV
    Feng, Jun
    Zhang, Zhiyuan
    Wallace, Michael B.
    Stafford, Jeffrey A.
    Kaldor, Stephen W.
    Kassel, Daniel B.
    Navre, Marc
    Shi, Lihong
    Skene, Robert J.
    Asakawa, Tomoko
    Takeuchi, Koji
    Xu, Rongda
    Webb, David R.
    Gwaltney, Stephen L., II
    JOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (10) : 2297 - 2300
  • [46] Recent patents of dipeptidyl peptidase IV inhibitors
    Mendieta, Laura
    Tarrago, Teresa
    Giralt, Ernest
    EXPERT OPINION ON THERAPEUTIC PATENTS, 2011, 21 (11) : 1693 - 1741
  • [47] Dipeptidyl peptidase iv inhibitors and diabetes therapy
    McIntosh, Christopher H. S.
    FRONTIERS IN BIOSCIENCE-LANDMARK, 2008, 13 : 1753 - 1773
  • [48] Dipeptidyl peptidase IV (DPP-IV) inhibition as a treatment for Type 2 diabetes
    Thornberry, NA
    FASEB JOURNAL, 2005, 19 (05): : A1723 - A1723
  • [49] Dipeptidyl peptidase IV (DPP-IV) inhibition as a treatment for type 2 diabetes
    Thornberry, N.
    FEBS JOURNAL, 2009, 276 : 77 - 77
  • [50] Discovery of β-homophenylalanine based pyrrolidin-2-ylmethyl amides and sulfonamides as highly potent and selective inhibitors of dipeptidyl peptidase IV
    Nordhoff, Sonja
    Cerezo-Galvez, Silvia
    Deppe, Holger
    Hill, Oliver
    Lopez-Canet, Meritxell
    Rummey, Christian
    Thiemann, Meinolf
    Matassa, Victor G.
    Edwards, Paul J.
    Feurer, Achim
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (15) : 4201 - 4203