A dihydrochalcone and several homoisoflavonoids from Polygonatum odoratum are activators of adenosine monophosphate-activated protein kinase

被引：55

作者：

Guo, Huanjie ^{[1
,2
]}

Zhao, Huanxin ^{[1
]}

Kanno, Yuichiro ^{[3
]}

Li, Wei ^{[3
]}

Mu, Yanling ^{[1
]}

Kuang, Xinzhu ^{[3
]}

Inouye, Yoshio ^{[3
]}

Koike, Kazuo ^{[3
]}

Jiang, Haipeng ^{[4
]}

Bai, Hong ^{[1
]}

机构：

[1] Shandong Acad Med Sci, Inst Mat Med, Jinan 250062, Shandong, Peoples R China

[2] Univ Jinan, Shandong Acad Med Sci, Sch Med & Life Sci, Jinan 250062, Shandong, Peoples R China

[3] Toho Univ, Fac Pharmaceut Sci, Funabashi, Chiba 2478510, Japan

[4] Wuhan Inst Technol, Sch Chem Engn & Pharm, Educ Minist, Key Lab Green Chem Proc, Wuhan 430073, Hubei, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 11期

关键词：

Polygonatum odoratum; Homoisoflavonoids; Dihydrochalcone; AMPK activation; EMERGING DRUG TARGET; RAT-LIVER; HOMOISOFLAVANONES;

D O I：

10.1016/j.bmcl.2013.04.027

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a major cellular energy sensor and master regulator of metabolic homeostasis; thus, AMPK plays a central role in studies on diabetes and related metabolic diseases. From the rhizomes of Polygonatum odoratum (Mill.) Druce, six homoisoflavonoids (1-6) and one dihydrochalcone (7) were isolated, and the structures of polygonatones A-D (4-7) were elucidated by various spectroscopic analyses. Compounds 1-7 were evaluated for their effect on AMPK activation. The amount of active phosphorylated AMPK and acetyl-CoA carboxylase in rat liver epithelial IAR-20 cells increased when the cells were incubated with the aforementioned compounds. Specifically, (3R)-5,7-dihydroxyl-6-methyl-8-methoxyl-3-(4'-hydroxylbenzyl)-chroman-4-one (1), (3R)-5,7-dihydroxyl- 6,8-dimethyl-3-(4'-hydroxylbenzyl)-chroman-4-one (2), (3R)-5,7-dihydroxyl-6-methyl-3-(4'-hydroxylbenzyl)-chroman-4-one (3), and polygonatone D (7) exhibited significant activation effects. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：3137 / 3139

页数：3

共 17 条

[1] ABSOLUTE-CONFIGURATION OF HOMOISOFLAVANONES FROM MUSCARI SPECIES [J].

ADINOLFI, M ;

BARONE, G ;

CORSARO, MM ;

MANGONI, L ;

LANZETTA, R ;

PARRILLI, M .

TETRAHEDRON, 1988, 44 (15) :4981-4988

[2]

[Anonymous], 1993, DICT TRADITIONAL CHI, V1, P1331

[3] A steroidal glycoside from Polygonatum odoratum (Mill.) Druce. improves insulin resistance but does not alter insulin secretion in 90% pancreatectomized rats [J].

Choi, SB ;

Park, S .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2002, 66 (10) :2036-2043

[4] REGULATION OF HMG-COA REDUCTASE - IDENTIFICATION OF THE SITE PHOSPHORYLATED BY THE AMP-ACTIVATED PROTEIN-KINASE INVITRO AND IN INTACT RAT-LIVER [J].

CLARKE, PR ;

HARDIE, DG .

EMBO JOURNAL, 1990, 9 (08) :2439-2446

[5] A stilbene and dihydrochalcones with radical scavenging activities from Loiseleuria procumbens [J].

Cuendet, M ;

Potterat, O ;

Salvi, A ;

Testa, B ;

Hostettmann, K .

PHYTOCHEMISTRY, 2000, 54 (08) :871-874

[6] Phenolic Compounds from Caesalpinia sappan Heartwood and Their Anti-inflammatory Activity [J].

Cuong, To Dao ;

Tran Manh Hung ;

Kim, Jin Cheol ;

Kim, Eun Hee ;

Woo, Mi Hee ;

Choi, Jae Sue ;

Lee, Jeong Hyung ;

Min, Byung Sun .

JOURNAL OF NATURAL PRODUCTS, 2012, 75 (12) :2069-2075

[7] DIURNAL RHYTHM OF PHOSPHORYLATION OF RAT-LIVER ACETYL COA CARBOXYLASE BY THE AMP-ACTIVATED PROTEIN-KINASE, DEMONSTRATED USING FREEZE-CLAMPING - EFFECTS OF HIGH-FAT DIETS [J].

DAVIES, SP ;

CARLING, D ;

MUNDAY, MR ;

HARDIE, DG .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1992, 203 (03) :615-623

[8] Saponin rich fractions from Polygonatum odoratum (Mill.) Druce with more potential hypoglycemic effects [J].

Deng, Yafei ;

He, Kai ;

Ye, Xiaoli ;

Chen, Xin ;

Huang, Jing ;

Li, Xuegang ;

Yuan, Lujiang ;

Jin, Yalan ;

Jin, Qing ;

Li, Panpan .

JOURNAL OF ETHNOPHARMACOLOGY, 2012, 141 (01) :228-233

[9] AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern [J].

Hardie, D. Grahame ;

Ross, Fiona A. ;

Hawley, Simon A. .

CHEMISTRY & BIOLOGY, 2012, 19 (10) :1222-1236

[10] 5′ AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle [J].

Kurth-Kraczek, EJ ;

Hirshman, MF ;

Goodyear, LJ ;

Winder, WW .

DIABETES, 1999, 48 (08) :1667-1671

← 1 2 →