Raman and Surface-Enhanced Raman Scattering (SERS) Studies of the Thrombin-Binding Aptamer

被引：10
作者：
Wu, Tsai-Chin [1 ]
Vasudev, Milana [1 ]
Dutta, Mitra [2 ,3 ]
Stroscio, Michael A. [1 ,2 ,3 ]
机构：
[1] Univ Illinois, Dept Bioengn, Chicago, IL 60607 USA
[2] Univ Illinois, Dept Elect & Comp Engn, Chicago, IL 60607 USA
[3] Univ Illinois, Dept Phys, Chicago, IL 60607 USA
来源：
IEEE TRANSACTIONS ON NANOBIOSCIENCE | 2013年 / 12卷 / 02期
关键词：
Aptamer; DNA; nanobiotechnology; nanoparticle; surface-enhanced Raman scattering; FLUOROMETRIC DETECTION; ENERGY-TRANSFER; DNA DETECTION; SPECTROSCOPY; QUADRUPLEX; SPECTRA; PROBES;
D O I：
10.1109/TNB.2013.2242484
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Surface-enhanced Raman scattering is used to study the Raman spectra and peak shifts the thrombin-binding aptamer (TBA) on substrates having two different geometries; one with a single stranded sequence and one with double stranded sequence. The Raman signals of the deoxyribonucleic acids on both substrates are enhanced and specific peaks of bases are identified. These results are highly reproducible and have promising applications in low cost nucleic acid detection.
引用
收藏
页码：93 / 97
页数：5
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