Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Contemporary Organ Dysfunction Criteria: Executive Summary

被引：49

作者：

Bembea, Melania M. ^{[1
]}

Agus, Michael ^{[4
]}

Akcan-Arikan, Ayse ^{[8
]}

Alexander, Peta ^{[5
,6
]}

Basu, Rajit ^{[12
]}

Bennett, Tellen D. ^{[14
,15
,16
]}

Bohn, Desmond ^{[17
]}

Brandao, Leonardo R. ^{[18
]}

Brown, Ann-Marie ^{[13
]}

Carcillo, Joseph A. ^{[19
]}

Checchia, Paul ^{[9
,10
,11
]}

Cholette, Jill ^{[21
]}

Cheifetz, Ira M. ^{[22
]}

Cornell, Timothy ^{[23
]}

Doctor, Allan ^{[24
]}

Eckerle, Michelle ^{[25
,26
]}

Erickson, Simon ^{[27
,28
]}

Farris, Reid W. D. ^{[29
]}

Faustino, E. Vincent S. ^{[30
]}

Fitzgerald, Julie C. ^{[31
,32
]}

Fuhrman, Dana Y. ^{[19
]}

Giuliano, John S., Jr. ^{[30
]}

Guilliams, Kristin ^{[33
,34
]}

Gaies, Michael ^{[36
]}

Gorga, Stephen M. ^{[36
]}

Hall, Mark ^{[37
]}

Hanson, Sheila J. ^{[38
]}

Hartman, Mary ^{[35
]}

Hassinger, Amanda B. ^{[39
]}

Irving, Sharon Y. ^{[40
]}

Jeffries, Howard ^{[29
]}

Jouvet, Philippe ^{[41
,42
]}

Kannan, Sujatha ^{[1
]}

Karam, Oliver ^{[43
]}

Khemani, Robinder G. ^{[44
,45
]}

Kissoon, Niranjan ^{[46
,47
]}

Lacroix, Jacques ^{[48
]}

Laussen, Peter ^{[5
,6
,7
]}

Leclerc, Francis ^{[49
]}

Lee, Jan Hau ^{[50
,51
]}

Leteurtre, Stephane ^{[49
]}

Lobner, Katie ^{[2
]}

McKiernan, Patrick J. ^{[20
]}

Menon, Kusum ^{[52
]}

Monagle, Paul ^{[53
]}

Muszynski, Jennifer A. ^{[37
]}

Odetola, Folafoluwa ^{[36
]}

Parker, Robert ^{[54
]}

Pathan, Nazima ^{[55
,56
]}

Pierce, Richard W. ^{[30
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Welch Med Lib, Baltimore, MD USA

[3] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[4] Boston Childrens Hosp, Div Med Crit Care, Boston, MA USA

[5] Boston Childrens Hosp, Dept Cardiol, Boston, MA USA

[6] Boston Childrens Hosp, Dept Pediat, Boston, MA USA

[7] Harvard Med Sch, Dept Anesthesiol Crit Care & Pain Med, Boston, MA 02115 USA

[8] Texas Childrens Hosp, Sect Crit Care, Dept Pediat, Houston, TX 77030 USA

[9] Texas Childrens Hosp, Dept Pediat, Sect Nephrol, Houston, TX 77030 USA

[10] Texas Childrens Hosp, Dept Pediat, Sect Crit Care Med, Houston, TX 77030 USA

[11] Baylor Coll Med, Houston, TX 77030 USA

[12] Childrens Healthcare Atlanta, Div Pediat Crit Care, Atlanta, GA USA

[13] Emory Univ, Nell Hodgson Woodruff Sch Nursing, Atlanta, GA 30322 USA

[14] Univ Colorado, Sch Med, Dept Pediat, Sect Informat & Data Sci, Aurora, CO USA

[15] Univ Colorado, Sch Med, Dept Pediat, Sect Crit Care Med, Aurora, CO USA

[16] Childrens Hosp Colorado, Aurora, CO USA

[17] Univ Toronto, Dept Crit Care Med, Hosp Sick Children, Toronto, ON, Canada

[18] Univ Toronto, Hosp Sick Children, Dept Paediat, Div Hematol Oncol, Toronto, ON, Canada

[19] Univ Pittsburgh, Sch Med, Dept Crit Care Med, Div Pediat Crit Care Med, Pittsburgh, PA USA

[20] UPMC Childrens Hosp Pittsburgh, Div Gastroenterol Hepatol & Nutr, Pittsburgh, PA USA

[21] Univ Rochester, Dept Pediat, Golisano Childrens Hosp, Rochester, NY USA

[22] Case Western Reserve Univ, Rainbow Babies & Childrens Hosp, Sch Med, Dept Pediat, Cleveland, OH USA

[23] Stanford Univ, Lucile Packard Childrens Hosp Stanford, Sch Med, Dept Pediat, Palo Alto, CA USA

[24] Univ Maryland, Ctr Blood Oxygen Transport & Hemostasis, Sch Med, Baltimore, MD USA

[25] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH USA

[26] Cincinnati Childrens Hosp Med Ctr, Div Emergency Med, Cincinnati, OH 45229 USA

[27] Perth Childrens Hosp, Dept Paediat Crit Care, Perth, WA, Australia

[28] Univ Western Australia, Perth, WA, Australia

[29] Univ Washington, Dept Pediat, Seattle Childrens Hosp, Seattle, WA 98195 USA

[30] Yale Sch Med, Dept Pediat, Sect Pediat Crit Care Med, New Haven, CT USA

[31] Univ Penn, Perelman Sch Med, Dept Anesthesiol & Crit Care, Philadelphia, PA USA

[32] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA

[33] Washington Univ, Sch Med, Dept Neurol, Div Pediat & Dev Neurol, St Louis, MO 63110 USA

[34] Washington Univ, Sch Med, Div Pediat Crit Care Med, St Louis, MO USA

[35] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA

[36] Univ Michigan, Dept Pediat, Ann Arbor, MI 48109 USA

[37] Ohio State Univ, Nationwide Childrens Hosp, Coll Med, Dept Pediat, Columbus, OH USA

[38] Med Coll Wisconsin, Dept Pediat, Crit Care Sect, Childrens Wisconsin, Milwaukee, WI USA

[39] Univ Buffalo, John R Oishei Childrens Hosp, Jacobs Sch Med & Biomed Sci, Dept Pediat, Buffalo, NY USA

[40] Univ Penn, Sch Nursing, Dept Family & Community Hlth, Philadelphia, PA USA

[41] St Justine Hosp, Dept Paediat, Montreal, PQ, Canada

[42] Univ Montreal, Montreal, PQ, Canada

[43] Virginia Commonwealth Univ, Childrens Hosp Richmond, Div Pediat Crit Care Med, Richmond, VA USA

[44] Childrens Hosp Los Angeles, Dept Anesthesiol & Crit Care Med, Los Angeles, CA 90027 USA

[45] Univ Southern Calif, Keck Sch Med, Los Angeles, CA USA

[46] Univ British Columbia, Dept Pediat, Div Crit Care, Vancouver, BC, Canada

[47] BC Childrens Hosp, Vancouver, BC, Canada

[48] Univ Montreal, Div Pediat Crit Care Med, Ctr Hosp Univ St Justine, Montreal, PQ, Canada

[49] Univ Lille, Ctr Hosp Univ Lille, ULR 2694 METR Evaluat Technol Sante & Prat Med, Lille, France

[50] KK Womens & Childrens Hosp, Childrens Intens Care Unit, Singapore, Singapore

来源：

PEDIATRICS | 2022年 / 149卷

基金：

美国国家卫生研究院;

关键词：

MORTALITY; EPIDEMIOLOGY; FAILURE; SEPSIS;

D O I：

10.1542/peds.2021-052888B

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Prior criteria for organ dysfunction in critically ill children were based mainly on expert opinion. We convened the Pediatric Organ Dysfunction Information Update Mandate (PODIUM) expert panel to summarize data characterizing single and multiple organ dysfunction and to derive contemporary criteria for pediatric organ dysfunction. The panel was composed of 88 members representing 47 institutions and 7 countries. We conducted systematic reviews of the literature to derive evidence-based criteria for single organ dysfunction for neurologic, cardiovascular, respiratory, gastrointestinal, acute liver, renal, hematologic, coagulation, endocrine, endothelial, and immune system dysfunction. We searched PubMed and Embase from January 1992 to January 2020. Study identification was accomplished using a combination of medical subject headings terms and keywords related to concepts of pediatric organ dysfunction. Electronic searches were performed by medical librarians. Studies were eligible for inclusion if the authors reported original data collected in critically ill children; evaluated performance characteristics of scoring tools or clinical assessments for organ dysfunction; and assessed a patient-centered, clinically meaningful outcome. Data were abstracted from each included study into an electronic data extraction form. Risk of bias was assessed using the Quality in Prognosis Studies tool. Consensus was achieved for a final set of 43 criteria for pediatric organ dysfunction through iterative voting and discussion. Although the PODIUM criteria for organ dysfunction were limited by available evidence and will require validation, they provide a contemporary foundation for researchers to identify and study single and multiple organ dysfunction in critically ill children.

引用

页码：S1 / S12

页数：12

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