Natural and vaccine-induced immunity and immunologic memory to Neisseria meningitidis serogroup C in young adults

被引：47
作者：
Goldblatt, D
Borrow, R
Miller, E
机构：
[1] Inst Child Hlth, Immunobiol Unit, London, England
[2] Publ Hlth Lab Serv, Ctr Communicable Dis Surveillance, Immunisat Div, London NW9 5EQ, England
[3] Withington Hosp, Publ Hlth Lab Serv, Meningococcal Reference Unit, Manchester M20 8LR, Lancs, England
来源：
JOURNAL OF INFECTIOUS DISEASES | 2002年 / 185卷 / 03期
关键词：
D O I：
10.1086/338474
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The immune response to polysaccharides and conjugate vaccines in adults is poorly understood. This study assessed meningococcal serogroup C responses after AC polysaccharide (MACP) and C conjugate (MCC) vaccine administration in young adults and explored immune memory by measuring antibody avidity. The geometric mean avidity indices (GMAIs) measured 1 month after MACP vaccination were relatively high and failed to increase significantly in the 6 months before and after a second dose of MACP/MCC. Although the GMAI of naive adults increased immediately following MCC vaccination to 215.7 (95% confidence interval, 181.0-257.1), a level similar to that seen after MACP vaccination, no further maturation in the subsequent 6 months was seen. Antibody induced by polysaccharide antigens in adults is already of relatively high avidity (compared with that in infants and toddlers) and fails to mature further, probably because both MACP and MCC predominantly stimulate memory B cells.
引用
收藏
页码：397 / 400
页数：4
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