Impact of hydroxymethylglutaryl coenzyme A reductase inhibition on left ventricular remodeling in patients with acute anterior myocardial infarction after primary coronary angioplasty

被引:6
作者
Ohara, Y [1 ]
Hiasa, Y [1 ]
Hosokawa, S [1 ]
Miyazaki, S [1 ]
Ogura, R [1 ]
Miyajima, H [1 ]
Yuba, K [1 ]
Suzuki, N [1 ]
Takahashi, T [1 ]
Kishi, K [1 ]
Ohtani, R [1 ]
机构
[1] Tokushima Red Cross Hosp, Div Cardiol, Komatsushima, Tokushima 7738502, Japan
关键词
statin; LV remodeling; AMI; coronary angioplasty;
D O I
10.1536/ihj.46.987
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Hydroxymethyglutaryl coenzyme A reductase inhibition (statin) therapy has been shown to reduce cardiac hypertrophy in vitro and in vivo. We assessed the influence of short-term statin therapy on left ventricular (LV) remodeling after acute myocardial infarction. Thirty-five patients with first anterior acute myocardial infarction, who underwent primary coronary angioplasty within 12 hours of onset, were divided into 2 groups. Ten patients taking statin served as the statin group, and 25 patients not taking statin served as the control group. Two-dimensional echocardiography was recorded after angioplasty (baseline) and at 4 weeks. LV ejection fraction (LVEF) at baseline was not significantly different between the 2 groups. However, the statin group had a higher LVEF at 4 weeks than the control group (58.2 +/- 5.0 versus 49.0 +/- 12.7%; P < 0.05). Moreover, the increase in LV end-diastolic Volume (LVEDV) at 4 weeks was lower in the statin group than in the control group (12.1 +/- 29.6 versus 39.9 +/- 35.7 mL; P < 0.05). Multiple regression analysis demonstrated that administration of statin was an independent factor for the increase in LVEDV (P < 0.05). These findings indicate that short-term statin therapy can prevent postinfarct LV remodeling and improve LV function.
引用
收藏
页码:987 / 995
页数:9
相关论文
共 29 条
  • [1] Effect of statin therapy on C-reactive protein levels - The Pravastatin Inflammation/CRP Evaluation (PRINCE): A randomized trial and cohort study
    Albert, MA
    Danielson, E
    Rifai, N
    Ridker, PM
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 286 (01): : 64 - 70
  • [2] ALVAREZ DS, 1999, J HYPERTENS, V17, P769
  • [3] THE EFFECT OF CHOLESTEROL-LOWERING AND ANTIOXIDANT THERAPY ON ENDOTHELIUM-DEPENDENT CORONARY VASOMOTION
    ANDERSON, TJ
    MEREDITH, IT
    YEUNG, AC
    FREI, B
    SELWYN, AP
    GANZ, P
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (08) : 488 - 493
  • [4] Left ventricular remodeling after primary coronary angioplasty - Patterns of left ventricular dilation and long-term prognostic implications
    Bolognese, L
    Neskovic, AN
    Parodi, G
    Cerisano, G
    Buonamici, P
    Santoro, GM
    Antoniucci, D
    [J]. CIRCULATION, 2002, 106 (18) : 2351 - 2357
  • [5] Effects of matrix metalloproteinase inhibition on ventricular remodeling due to volume overload
    Chancey, AL
    Brower, GL
    Peterson, JT
    Janicki, JS
    [J]. CIRCULATION, 2002, 105 (16) : 1983 - 1988
  • [6] REGULATION OF COLLAGEN DEGRADATION IN THE RAT MYOCARDIUM AFTER INFARCTION
    CLEUTJENS, JPM
    KANDALA, JC
    GUARDA, E
    GUNTAKA, RV
    WEBER, KT
    [J]. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1995, 27 (06) : 1281 - 1292
  • [7] Left ventricular remodeling with carvedilol in patients with congestive heart failure due to ischemic heart disease
    Doughty, RN
    Whalley, GA
    Gamble, G
    MacMahon, S
    Sharpe, N
    Krum, H
    Murray, Y
    Tonkin, A
    Trotter, A
    Burton, R
    Garrett, J
    Lane, G
    Watts, J
    Geddes, C
    Hall, C
    Stephensen, J
    Woodhouse, S
    Davidson, T
    Bradbury, J
    Hamer, A
    Hopkins, L
    Jackson, D
    Cross, D
    Moreland, F
    Hawtin, B
    Kimber, V
    Saunders, M
    Thomson, A
    Colquhoun, D
    Goldsmith, J
    Hicks, B
    Bond, C
    Flett, S
    Murphy, J
    Bruning, J
    Jellyman, T
    Nairn, L
    Bartram, H
    McCulloch, A
    Milne, A
    Prasad, R
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1997, 29 (05) : 1060 - 1066
  • [8] Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells
    Hernández-Perera, O
    Pérez-Sala, D
    Navarro-Antolín, J
    Sánchez-Pascuala, R
    Hernández, G
    Díaz, C
    Lamas, S
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (12) : 2711 - 2719
  • [9] Lipophilic HMG-CoA reductase inhibitor has an anti-inflammatory effect -: Reduction of MRNA levels for interleukin-1β, interleukin-6, cyclooxygenase-2, and p22phox by regulation of peroxisome proliferator-activated receptor α (PPARα) in primary endothelial cells
    Inoue, I
    Goto, S
    Mizotani, K
    Awata, T
    Mastunaga, T
    Kawai, S
    Nakajima, T
    Hokari, S
    Komoda, T
    Katayama, S
    [J]. LIFE SCIENCES, 2000, 67 (08) : 863 - 876
  • [10] The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals.
    Kureishi, Y
    Luo, ZY
    Shiojima, I
    Bialik, A
    Fulton, D
    Lefer, DJ
    Sessa, WC
    Walsh, K
    [J]. NATURE MEDICINE, 2000, 6 (09) : 1004 - 1010