Extracts of Scrophularia frigida Boiss display potent antitumor effects in human breast cancer cells by inducing apoptosis and inhibition of expression of the human epidermal growth factor receptor 2

被引：5

作者：

Goldar, S. ^{[1
,2
,3
,4
]}

Baradaran, B. ^{[2
]}

Khaniani, M. Shekari ^{[2
,3
]}

Azadmehr, A. ^{[5
]}

Derakhshan, S. M. ^{[3
]}

Mohammadi, A. ^{[2
]}

Mansoori, B. ^{[2
]}

Khaze, V. ^{[2
]}

Shanehbandi, D. ^{[2
]}

Mohammadnejad, L. ^{[2
]}

Baghbani, E. ^{[2
]}

机构：

[1] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran

[2] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran

[3] Tabriz Univ Med Sci, Fac Med, Dept Med Genet, Tabriz, Iran

[4] Tabriz Univ Med Sci, Students Res Comm, Tabriz, Iran

[5] Babol Univ Med Sci, Fac Med, Div Immunol, Babol Sar, Iran

来源：

CELLULAR AND MOLECULAR BIOLOGY | 2016年 / 62卷 / 09期

关键词：

Antitumor; Scrophularia frigida Boiss; apoptosis; HER2; expression; SKBR3; cells; IN-VITRO; IRIDOID GLYCOSIDES; DOWN-REGULATION; HER2/NEU; MCF-7; BUERGERIANA; OXYSEPALA; ABSENCE; ERBB2; GENE;

D O I：

10.14715/cmb/2016.62.9.13

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Some species of the Scrophularia genus have been extensively used as a natural remedy for treatment of various medical conditions. The objective of this study was to evaluate the growth inhibitory activity of Scrophularia frigida Boiss extracts as well as to study the effect of the potent extracts on the induction of apoptosis and cell cycle arrest on human breast cancer cells. S. frigida Boiss extracts exhibited obvious inhibitory effects on the growth of cancer cells and induced apoptosis. It is suggested that the extracts exert their anti-proliferative effect through multiple implications such as suppressing growth, arresting the cell cycle, increased DNA fragmentation, downregulation of the expression of human epidermal growth factor receptor 2 and myeloid cell Leukemia-1, and upregulation of pro-apoptotic messenger RNAs like caspase-3 and caspase-9. Taken together, the results obtained indicate that S. frigida Boiss extracts may contain effective compounds that can be used as a therapeutic anticancer agent.

引用

页码：83 / 89

页数：7

共 42 条

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