Facing the Truth about Nanotechnology in Drug Delivery

被引：420

作者：

Park, Kinam ^{[1
,2
]}

机构：

[1] Purdue Univ, Dept Biomed Engn, W Lafayette, IN 47906 USA

[2] Purdue Univ, Dept Pharmaceut, W Lafayette, IN 47906 USA

来源：

ACS NANO | 2013年 / 7卷 / 09期

关键词：

SOLID TUMORS; EXTRAVASCULAR TRANSPORT; CANCER-CHEMOTHERAPY; IN-VITRO; LIPOSOMES; NANOPARTICLES; MECHANISM; SYSTEMS; VIVO;

D O I：

10.1021/nn404501g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nanotechnology in drug delivery has been manifested into nanoparticles that can have unique properties both in vitro and in vivo, especially in targeted drug delivery to tumors. Numerous nanoparticle formulations have been designed and tested to great effect in small animal models, but the translation of the small animal results to clinical success has been limited. Successful translation requires revisiting the meaning of nanotechnology in drug delivery, understanding the limitations of nanoparticles, identifying the misconceptions pervasive in the field, and facing inconvenient truths. Nanoparticle approaches can have real impact in improving drug delivery by focusing on the problems at hand, such as enhancing their drug loading capacity, affinity to target cells, and spatiotemporal control of drug release.

引用

页码：7442 / 7447

页数：6

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