Emerging role of interleukin-33 in autoimmune diseases

被引：98

作者：

Pei, Cheng ^{[1
,2
]}

Barbour, Mark ^{[1
]}

Fairlie-Clarke, Karen J. ^{[1
]}

Allan, Debbie ^{[1
]}

Mu, Rong ^{[3
]}

Jiang, Hui-Rong ^{[1
]}

机构：

[1] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow G4 0RE, Lanark, Scotland

[2] Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 1, Dept Ophthalmol, Xian 710049, Peoples R China

[3] Peking Univ, Peoples Hosp, Inst Rheumatol & Immunol, Beijing 100871, Peoples R China

来源：

IMMUNOLOGY | 2014年 / 141卷 / 01期

关键词：

autoimmune diseases; inflammation; interleukin-33; ST2; INFLAMMATORY-BOWEL-DISEASE; SOLUBLE ST2; AIRWAY INFLAMMATION; ULCERATIVE-COLITIS; INDUCED ARTHRITIS; IL-33; EXPRESSION; CROHNS-DISEASE; CYTOKINE IL-33; RECEPTOR ST2; SERUM-LEVELS;

D O I：

10.1111/imm.12174

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interleukin-33 (IL-33) is a member of the IL-1 cytokine family. It predominantly induces type 2 immune responses and thus is protective against atherosclerosis and nematode infections but contributes to allergic airway inflammation. Interleukin-33 also plays a pivotal role in the development of many autoimmune diseases through mechanisms that are still not fully understood. In this review, we focus on the recent advances in understanding of the expression and function of IL-33 in some autoimmune disorders, aiming to provide insight into its potential role in disease development.

引用

页码：9 / 17

页数：9

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