Cytomegalovirus-related congenital nephrotic syndrome with diffuse mesangial sclerosis

被引：40
作者：
Besbas, N
Bayrakci, US [1 ]
Kale, G
Cengiz, AB
Akcoren, Z
Akinci, D
Kilic, I
Bakkaloglu, A
机构：
[1] Hacettepe Univ, Fac Med, Dept Pediat Nephrol, Ankara, Turkey
[2] Hacettepe Univ, Fac Med, Dept Publ Pathol, Ankara, Turkey
[3] Hacettepe Univ, Fac Med, Dept Pediat Infect Dis, Ankara, Turkey
[4] Hacettepe Univ, Fac Med, Dept Radiol, Ankara, Turkey
[5] Hacettepe Univ, Fac Med, Dept Pediat, Ankara, Turkey
来源：
PEDIATRIC NEPHROLOGY | 2006年 / 21卷 / 05期
关键词：
early onset nephrotic syndrome; cytomegalovirus; diffuse mesangial sclerosis; treatment; ganciclovir;
D O I：
10.1007/s00467-006-0051-4
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
This case report describes congenital nephrotic syndrome in a 2-month-old girl associated with cytomegalovirus infection. Histological examination on renal biopsy showed diffuse mesangial sclerosis and cytomegalic inclusion bodies in the tubular cells and in some glomeruli. Cytomegalovirus (CMV) polymerase chain reaction (PCR) titer in serum was high. Remission of pulmonary and renal symptoms was achieved with ganciclovir in 3 weeks. No recurrence of proteinuria was observed during the follow-up period of 14 months. These finding suggested a causal relationship between congenital nephrotic syndrome and cytomegalovirus infection.
引用
收藏
页码：740 / 742
页数：3
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