Quantum Dots as Multimodal Photoacoustic and Photothermal Contrast Agents

被引：122

作者：

Shashkov, Evgeny V. ^{[1
,2
]}

Everts, Maaike ^{[3
]}

Galanzha, Ekaterina I. ^{[1
,4
]}

Zharov, Vladimir P. ^{[1
]}

机构：

[1] Univ Arkansas Med Sci, Philips Class Laser Labs, Little Rock, AR 72205 USA

[2] Prokhorov Gen Phys Inst, Moscow 119991, Russia

[3] Univ Alabama, Div Human Gene Therapy, Birmingham, AL 35294 USA

[4] Saratov NG Chernyshevskii State Univ, Inst Opt & Biophoton, Saratov 410012, Russia

来源：

NANO LETTERS | 2008年 / 8卷 / 11期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1021/nl802442x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Quantum dots (QDs) have primarily been developed as fluorescent probes with unique optical properties. We herein demonstrate an extension of these OD utilities to photoacoustic (PA) and photothermal (PT) microscopy, using a nanosecond pulse laser excitation (420-900 nm, 8 ns, 10(-3)-10 J/cm(2)). The laser-induced PA, PT and accompanying bubble formation phenomena were studied with an advanced multifunctional microscope, which integrates fluorescence, PA, PT imaging, and PT thermolens modules. It was demonstrated that QDs, in addition to being excellent fluorescent probes, can be used as PA and PT contrast agents and sensitizers, thereby providing an opportunity for multimodal high resolution (300 nm) PA-PT-fluorescent imaging as well as PT therapy. Further improvements for this technology are suggested by increasing the conversion of laser energy in PT, PA, and bubble phenomena in hybrid multilayer QDs that have optimized absorption, thermal, and acoustic properties.

引用

页码：3953 / 3958

页数：6

共 21 条

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