Heat stress response of male germ cells

被引：118
作者：
Kim, Byunghyuk [1 ]
Park, Kyosun [1 ]
Rhee, Kunsoo [1 ]
机构：
[1] Seoul Natl Univ, Dept Biol Sci, Seoul 151747, South Korea
来源：
CELLULAR AND MOLECULAR LIFE SCIENCES | 2013年 / 70卷 / 15期
关键词：
Hyperthermia; Spermatogenesis; Infertility; Heat stress; Germ cell apoptosis; DNA damage; Stress granules; NITRIC-OXIDE SYNTHASE; SHOCK TRANSCRIPTION FACTOR-1; RAT SEMINIFEROUS EPITHELIUM; DOLPHIN TURSIOPS-TRUNCATUS; OXIDATIVE STRESS; EXPERIMENTAL CRYPTORCHIDISM; MOUSE TESTIS; IN-VIVO; TEMPERATURE REGULATION; SPERMATOGENIC CELLS;
D O I：
10.1007/s00018-012-1165-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The vast majority of mammalian testes are located outside the body cavity for proper thermoregulation. Heat has an adverse effect on mammalian spermatogenesis and eventually leads to sub- or infertility. Recent studies have provided insights into the molecular response of male germ cells to high temperatures. Here, we review the effects of heat on male germ cells and discuss the mechanisms underlying germ cell loss and impairment. We also discuss the role of translational control in male germ cells as a potential protective mechanism against heat-induced germ cell apoptosis.
引用
收藏
页码：2623 / 2636
页数：14
相关论文
共 184 条
  • [21] Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition
    Chen, Jing
    Melton, Collin
    Suh, Nayoung
    Oh, Jeong Su
    Horner, Kathleen
    Xie, Fang
    Sette, Claudio
    Blelloch, Robert
    Conti, Marco
    [J]. GENES & DEVELOPMENT, 2011, 25 (07) : 755 - 766
  • [22] Effect of heat stress on expression of junction-associated molecules and upstream factors androgen receptor and Wilms' tumor 1 in monkey sertoli cells
    Chen, Min
    Cai, Huan
    Yang, Jun-Ling
    Lu, Cui-Ling
    Liu, Tao
    Yang, Wei
    Guo, Jian
    Hu, Xiao-Qian
    Fan, Cui-Hong
    Hu, Zhao-Yuan
    Gao, Fei
    Liu, Yi-Xun
    [J]. ENDOCRINOLOGY, 2008, 149 (10) : 4871 - 4882
  • [23] CYCLE OF SEMINIFEROUS EPITHELIUM IN MAN
    CLERMONT, Y
    [J]. AMERICAN JOURNAL OF ANATOMY, 1963, 112 (01): : 35 - &
  • [24] The DAZL family proteins are PABP-binding proteins that regulate translation in germ cells
    Collier, B
    Gorgoni, B
    Loveridge, C
    Cooke, HJ
    Gray, NK
    [J]. EMBO JOURNAL, 2005, 24 (14) : 2656 - 2666
  • [25] STUDIES ON STRUCTURE AND FUNCTION OF MAMMALIAN TESTIS .2. CYTOLOGICAL AND HISTOCHEMICAL OBSERVATIONS ON TESTIS OF RAT AFTER A SINGLE EXPOSURE TO HEAT APPLIED FOR DIFFERENT LENGTHS OF TIME
    COLLINS, P
    LACY, D
    [J]. PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1969, 172 (1026): : 17 - +
  • [26] Mouse models of male infertility
    Cooke, HJ
    Saunders, PTK
    [J]. NATURE REVIEWS GENETICS, 2002, 3 (10) : 790 - 801
  • [27] Modulation of germ cell apoptosis with a nitric oxide synthase inhibitor in a murine model of congenital cryptorchidism
    DeFoor, WR
    Kuan, CY
    Pinkerton, M
    Sheldon, CA
    Lewis, AG
    [J]. JOURNAL OF UROLOGY, 2004, 172 (04) : 1731 - 1735
  • [28] Activation of GCN2 in UV-irradiated cells inhibits translation
    Deng, J
    Harding, HP
    Raught, B
    Gingras, AC
    Berlanga, JJ
    Scheuner, D
    Kaufman, RJ
    Ron, D
    Sonenberg, N
    [J]. CURRENT BIOLOGY, 2002, 12 (15) : 1279 - 1286
  • [29] Gene-specific regulation by general translation factors
    Dever, TE
    [J]. CELL, 2002, 108 (04) : 545 - 556
  • [30] PHOSPHORYLATION OF INITIATION FACTOR-2-ALPHA BY PROTEIN-KINASE GCN2 MEDIATES GENE-SPECIFIC TRANSLATIONAL CONTROL OF GCN4 IN YEAST
    DEVER, TE
    FENG, L
    WEK, RC
    CIGAN, AM
    DONAHUE, TF
    HINNEBUSCH, AG
    [J]. CELL, 1992, 68 (03) : 585 - 596
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