Tackling the increasing complexity of therapeutic monoclonal antibodies with mass spectrometry

被引：14
作者：
Rosati, Sara [1 ,2 ,3 ]
Thompson, Natalie J. [1 ,2 ,3 ]
Heck, Albert J. R. [1 ,2 ,3 ]
机构：
[1] Univ Utrecht, Bijvoet Ctr Biomol Res, NL-3584 CH Utrecht, Netherlands
[2] Univ Utrecht, Utrecht Inst Pharmaceut Sci, NL-3584 CH Utrecht, Netherlands
[3] Netherlands Prote Ctr, NL-3584 CH Utrecht, Netherlands
来源：
TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2013年 / 48卷
关键词：
Analytical method; Antibody (Ab); Antibody-drug conjugate (ADC); Biopharmaceutical; Biosimilar; Bispecific antibody; Glycosylation; Mass spectrometry; Native mass spectrometry; Sequence variant; FAB-ARM EXCHANGE; ELECTROSPRAY-IONIZATION; INTERACTION STRENGTH; INTACT ANTIBODIES; IGG; BIOPHARMACEUTICALS; GLYCOSYLATION; TECHNOLOGIES; BIOSIMILARS; GENERATION;
D O I：
10.1016/j.trac.2013.02.013
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Mass spectrometry (MS) is emerging as an efficient method for the structural analysis of various new antibody-based therapeutic products. Here, we review the current trends and describe recent applications that highlight the use of MS to tackle the increasing complexity of monoclonal antibodies. (C) 2013 Elsevier Ltd. All rights reserved.
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收藏
页码：72 / 80
页数：9
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