Eda Yildirim, Jeannie Lee and colleagues present intriguing evidence that the long non-coding RNA X-inactive specific transcript (Xist) is required for maintaining X-chromosome inactivation, and that the loss of Xistafter X inactivation can cause haematopoietic cancers in mice.
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Yildirim E(2013)Xist RNA is a potent suppressor of hematologic cancer in mice Cell 152 727-742